Journal of Natural Medicines

, Volume 71, Issue 1, pp 305–309 | Cite as

Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata

  • Zhongnan Wu
  • Yubo Zhang
  • Li Yang
  • Nenghua Chen
  • Lin Jiang
  • Siqi Jiang
  • Guoqiang Li
  • Yaolan Li
  • Guocai Wang
Note
  • 241 Downloads

Abstract

Three new ent-kaurane diterpenes, 3α-angeloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (1), 3α-tigloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (2) and 3α-cinnamoyloxykaur-9(11),16-dien-19-oic acid (3), along with five known compounds (4-8), were isolated from the herbs of Wedelia prostrata (Asteraceae). The structures were determined by extensive analysis of their spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolated compounds were evaluated for their cytotoxic activity on human hepatocellular carcinoma HepG2 cells. Among them, all isolates exhibited cytotoxic activities with IC50 values ranging from 9.55 ± 0.45 to 53.92 ± 1.22 μM.

Keywords

Wedelia prostrata Asteraceae ent-kaurane diterpenes Cytotoxic activity 

Notes

Acknowledgments

This work was supported financially by the Natural Science Foundations of China (Nos. 81673319, 81202429, 81273390 and 81473116), the Natural Science Foundation of Guangdong Province (No. S2013020012864) and 111 Project (No. B13038).

Supplementary material

11418_2016_1037_MOESM1_ESM.docx (1.7 mb)
Supplementary material 1 (DOCX 1704 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Zhongnan Wu
    • 1
  • Yubo Zhang
    • 1
  • Li Yang
    • 1
  • Nenghua Chen
    • 1
  • Lin Jiang
    • 1
  • Siqi Jiang
    • 1
  • Guoqiang Li
    • 1
  • Yaolan Li
    • 1
  • Guocai Wang
    • 1
  1. 1.Institute of Traditional Chinese Medicine and Natural Products, College of PharmacyJinan UniversityGuangzhouPeople’s Republic of China

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