Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata
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Three new ent-kaurane diterpenes, 3α-angeloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (1), 3α-tigloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (2) and 3α-cinnamoyloxykaur-9(11),16-dien-19-oic acid (3), along with five known compounds (4-8), were isolated from the herbs of Wedelia prostrata (Asteraceae). The structures were determined by extensive analysis of their spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolated compounds were evaluated for their cytotoxic activity on human hepatocellular carcinoma HepG2 cells. Among them, all isolates exhibited cytotoxic activities with IC50 values ranging from 9.55 ± 0.45 to 53.92 ± 1.22 μM.
KeywordsWedelia prostrata Asteraceae ent-kaurane diterpenes Cytotoxic activity
This work was supported financially by the Natural Science Foundations of China (Nos. 81673319, 81202429, 81273390 and 81473116), the Natural Science Foundation of Guangdong Province (No. S2013020012864) and 111 Project (No. B13038).
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