Journal of Natural Medicines

, Volume 71, Issue 1, pp 59–67 | Cite as

Efficacy of Kaempferia parviflora in a mouse model of obesity-induced dermatopathy

  • Moeko Hidaka
  • Kazumasa Horikawa
  • Tomoko Akase
  • Hiroko Makihara
  • Takatoshi Ogami
  • Hiroshi Tomozawa
  • Masahito Tsubata
  • Ai Ibuki
  • Yutaka Matsumoto
Original Paper


Obesity results from excessive energy intake and physical inactivity, and predisposes one to various diseases. One of these reasons is that enlargement of adipocytes raises the lipid metabolic abnormalities that affect various organs. The skin is one such organ, and it has been reported that subcutaneous adipocyte cells secrete various factors and these factors are involved in reduction of dermal collagen fibers and fragility of the skin in obesity. The present study explored the efficacy of Kaempferia parviflora (KP) in preventing obesity-induced dermatopathy. We used Tsumura Suzuki obese diabetes (TSOD) mice as an obesity model. TSOD mice were fed a standard diet (MF) mixed with either an ethanol extract from KP (KPE), polymethoxyflavonoid-rich extract from KP (PMF), or polymethoxyflavonoid-poor extract from KP (X). We then evaluated the effect of these three KP fractions on aging-like skin damage induced by UVB irradiation. KPE and PMF caused a significant decrease of mouse body weight, and suppressed the increase in the thickness of the subcutaneous fat layer. In addition, KPE shifted the frequency of subcutaneous adipocyte sizes towards smaller cells possibly via its polypharmacological actions. Scanning electron microscopy revealed that the stereostructure of the collagenous fibers in the dermis was better retained in the KPE and PMF groups, in that order. These results offer the first evidence that KPE can attenuate obesity-induced dermatopathy more effectively than PMF, suggesting that KPE (or KP) might be a candidate supplement for preventing obesity-related skin disorders.


Kaempferia parviflora Obesity Skin disorder Dermis Subcutaneous fat 



This work was supported by a grant-in-aid for Scientific Research from MEXT (Ministry of Education Culture, Sports, Science and Technology) (No. 1224593252).

Supplementary material

11418_2016_1027_MOESM1_ESM.docx (28 kb)
Supplementary material 1 (DOCX 27 kb)


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  1. 1.Department of Biological Science and Nursing, School of MedicineYokohama City UniversityYokohamaJapan
  2. 2.Department of Molecular Pharmacology and Neurobiology, Graduate School of MedicineYokohama City UniversityYokohamaJapan
  3. 3.Research and Development DivisionToyo Shinyaku Co., Ltd.,TosuJapan

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