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New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis

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Abstract

Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2′-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on 13C- and 1H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.

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Acknowledgments

The authors are grateful to Prof. Dr. Muhammad Iqbal Choudhary, and the H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, for their generous support.

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Authors and Affiliations

  1. Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran

    Syed Mustafa Ghanadian

  2. Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

    Abdul Majid Ayatollahi

  3. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran

    Suleiman Afsharypuor

  4. Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran

    Shaghayegh Haghjooy Javanmard & Nasim Dana

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  1. Syed Mustafa Ghanadian
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  2. Abdul Majid Ayatollahi
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  3. Suleiman Afsharypuor
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  4. Shaghayegh Haghjooy Javanmard
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Correspondence to Abdul Majid Ayatollahi.

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Ghanadian, S.M., Ayatollahi, A.M., Afsharypuor, S. et al. New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis. J Nat Med 67, 327–332 (2013). https://doi.org/10.1007/s11418-012-0686-3

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  • DOI: https://doi.org/10.1007/s11418-012-0686-3

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