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Sanjecumins A and B: new limonoids from Sandoricum koetjape

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Abstract

Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant from the Open Research Center Project of Hoshi University.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Takahiro Hosoya & Hiroshi Morita

  2. Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, Indonesia

    Abdul Rahman, Idha Kusumawati & Noor Cholies Zaini

Authors
  1. Yuta Nagakura
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  2. Alfarius Eko Nugroho
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  3. Yusuke Hirasawa
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  4. Takahiro Hosoya
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  5. Abdul Rahman
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  6. Idha Kusumawati
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  7. Noor Cholies Zaini
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  8. Hiroshi Morita
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Correspondence to Hiroshi Morita.

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Nagakura, Y., Nugroho, A.E., Hirasawa, Y. et al. Sanjecumins A and B: new limonoids from Sandoricum koetjape . J Nat Med 67, 381–385 (2013). https://doi.org/10.1007/s11418-012-0677-4

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  • DOI: https://doi.org/10.1007/s11418-012-0677-4

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