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Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice

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Abstract

Fifteen derivatives of falconensin were examined for their inhibitory activity against the induction of ear edema in mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects. All compounds tested, except monomethylmitorubrin, inhibited the inflammatory activity induced by TPA.

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Authors and Affiliations

  1. College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba, 274-8555, Japan

    Ken Yasukawa & Michio Takido

  2. Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, 142-8501, Japan

    Takeshi Itabashi & Ken-ichi Kawai

Authors
  1. Ken Yasukawa
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  2. Takeshi Itabashi
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  3. Ken-ichi Kawai
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  4. Michio Takido
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Corresponding author

Correspondence to Ken Yasukawa.

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Yasukawa, K., Itabashi, T., Kawai, Ki. et al. Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice. J Nat Med 62, 384–386 (2008). https://doi.org/10.1007/s11418-008-0250-3

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  • DOI: https://doi.org/10.1007/s11418-008-0250-3

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