Table 1 The effect of xenoestrogens and 17β-estradiol on micronucleus formation in MCF-7 cells

From: In vitro estrogenic, cytotoxic, and genotoxic profiles of the xenoestrogens 8-prenylnaringenine, genistein and tartrazine

Group Conc (M) Micronuclei per 1000 binucleated cells* Fold Trend
Replicates Average SD
Benzo[a]pyrene 10−9 91 86 94 90.33 4.04 8.74  
Untreated   11 12 8 10.33 2.08  
Vehicle control 0.1% EtOH 7 10 13 10 3  
17 β-estradiol 10−8 12 14 13 13 1 1.26 p = 0.91
10−7 10 13 17 13.33 3.51 1.29
8-PN 10−8 16 19 21 18.67 2.52 1.81 p = 0.32
10−7 24 20 23 22.33 2.08 2.16
Genistein 10−8 14 16 16 15.33 1.15 1.48 p = 0.61
10−7 17 15 19 17 2 1.65
Tartrazine 10−8 21 19 25 21.67 3.06 2.10 p = 0.07
10−7 29 31 27 29 2 2.81
  1. *Values represent the mean ± SD of three replicates in a single experiment
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