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Effects of fucoidan on the hematic indicators and antioxidative responses of Nile tilapia (Oreochromis niloticus) fed diets contaminated with aflatoxin B1

Environmental Science and Pollution Research volume 27, pages 12579–12586 (2020)Cite this article

Abstract

Fucoidan is a rich source of medicinally active immunostimulants that possess various pharmacological properties. This study examined the potential impact of fucoidan on the hematic indicators and antioxidative responses of Nile tilapia fed diets contaminated with aflatoxin B1 (AFB1). Fish (60 ± 6.1 g) were allocated to five groups; the first (control) and second groups were fed 0% or 1% fucoidan–supplemented diets without AFB1 contamination, while the third, fourth, and fifth groups were fed diets contaminated with AFB1 and supplemented with 0%, 0.5%, and 1% fucoidan, respectively. After 30 days, fish fed AFB1 showed high ALT, AST, ALP, cholesterol, urea, and creatinine levels; furthermore, total blood protein and tissue (liver, kidney, and gill) glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activity significantly (P ≤ 0.05) decreased in fish fed AFB1, while tissue malondialdehyde significantly increased (P ≤ 0.05). Interestingly, fish fed fucoidan showed decreased ALT, AST, ALP, cholesterol, urea, and creatinine, as well as increased blood protein, GSH, GPx, SOD, and CAT activity. The results suggested that fucoidan is capable of inducing protective activity against AFB1 toxicity in Nile tilapia by enhancing the serum biochemical and tissue antioxidant responses of fish.

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Funding

This work was funded by Researchers Supporting Project number (RSP 2019/ 121), King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia

    Mohamed M. Abdel-Daim & Saad Alkahtani

  2. Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt

    Mohamed M. Abdel-Daim

  3. Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt

    Mahmoud A.O. Dawood

  4. Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, F-25030, Besançon Cedex, France

    Lotfi Aleya

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  1. Mohamed M. Abdel-Daim
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  2. Mahmoud A.O. Dawood
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  4. Saad Alkahtani
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Correspondence to Mohamed M. Abdel-Daim or Mahmoud A.O. Dawood.

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Abdel-Daim, M.M., Dawood, M.A., Aleya, L. et al. Effects of fucoidan on the hematic indicators and antioxidative responses of Nile tilapia (Oreochromis niloticus) fed diets contaminated with aflatoxin B1. Environ Sci Pollut Res 27, 12579–12586 (2020). https://doi.org/10.1007/s11356-020-07854-w

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Keywords

  • Blood health
  • Aflatoxin B1
  • Oreochromis niloticus
  • Oxidative and antioxidative responses
  • Fucoidan