Residue behavior and risk assessment of thifluzamide in the maize field ecosystem

Research Article
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Abstract

In the present work, the dissipation kinetics and final residue levels of thifluzamide in the maize field ecosystem were investigated. Using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction combined with liquid chromatography-tandem mass spectrometric detection (LC-MS/MS), a rapid, sensitive, efficient, and reliable method for extraction and quantitative analysis of thifluzamide residues in maize grain, maize plant, and soil was developed. Satisfactory recoveries of 78.7–97.0% were achieved with relative standard deviations (RSDs) in the range of 1.6 to 8.2%. The limits of detection (LODs) and the limit of quantification (LOQ) were 0.002–0.005 and 0.010 mg kg−1, respectively. The dissipation kinetics of thifluzamide in maize plant was well fitted by the first-order kinetic model with short half-lives of 0.19–0.22 days, while thifluzamide degraded slowly in soil with half-lives of 4.56–15.85 days. The final residues in maize grain, maize plant, and soil samples collected at the milk stage and the physiological maturity stage were no more than 0.010, 0.807, and 0.278 mg kg−1, respectively. Given that no maximum residue limit (MRL) for thifluzamide in maize has been established, the safety of this fungicide application was estimated by a dietary risk assessment. The hazard quotient was 0.03%, which was substantially less than 1, indicating that the long-term risk induced by the thifluzamide application on maize at the recommended dose is negligible. These results help governments to develop regulations for the safe use of thifluzamide.

Keywords

Thifluzamide Dissipation behavior Final residues Risk assessment Maize LC-MS/MS Modified QuEChERS extraction 

Notes

Acknowledgements

This work was supported by the National Key R&D Program of China (No. 2016YFD0400800), the National Natural Science Foundation of China (No. 31401590), and the Central Public-Interest Scientific Institution Basal Research Fund (No. 1610072017007).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11356_2018_2211_MOESM1_ESM.doc (1.1 mb)
Fig. S1 LC-MS/MS chromatograms of thifluzamide: blank maize plant (a), standard in maize plant at 0.100 mg kg−1 (b), maize plant spiked at 0.100 mg kg−1 (c), maize plant sample collected in Heilongjiang after 10 days of the application (d), blank soil (e), standard in soil at 0.100 mg kg−1 (f), soil spiked at 0.100 mg kg−1 (g), and soil sample collected after 28 days of the last application at the milk stage (field site: Henan; spray frequency: 2; application dose: 202.5 g a.i. ha−1) (h) (DOC 1175 kb)

References

  1. Carpenter KLH, Veen CVD, Hird R, Dennis IF, Ding T, Mitchinson MJ (1997) The carotenoids β-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDL oxidation. FEBS Lett 401(2–3):262–266CrossRefGoogle Scholar
  2. Chen WT, Li MH, Li WX, Han LJ (2015) Dissipation and residue level of thifluzamide in rice field ecosystem. J Chem 2015:1–8Google Scholar
  3. Chinese Ministry of Agriculture (2004) Guideline on pesticide residue trials. NY/T 788–2004Google Scholar
  4. Chinese Ministry of Agriculture (2016) National food safety standard-Maximum residue limits for pesticides in food, GB 2763–2016Google Scholar
  5. Chinese National Bureau of Statistics (2016) Bulletin on grain output in 2016 (China). http://www.stats.gov.cn/tjsj/zxfb/201612/t20161208_1439012.html. Accessed 30 Dec 201
  6. Chinese Society of Nutrition (2011) The Chinese dietary guidelines. The Tibet People’s Publishing House, TibetGoogle Scholar
  7. Duan TT, Zhang Y, Wei J, Zhu F (2014) Determination of thifluzamide residues in rice, corn and potato using UPLC MS/MS. J Instrum Anal 33(5):598–601Google Scholar
  8. Famiglini G, Palma P, Pierini E, Trufelli H, Cappiello A (2008) Organochlorine Pesticides by LC−MS. Anal Chem 80(9):3445–3449CrossRefGoogle Scholar
  9. Fantke P, Jolliet O (2016) Life cycle human health impacts of 875 pesticides. Int J Life Cycle Assess 21(5):722–733CrossRefGoogle Scholar
  10. Fantke P, Juraske R (2013) Variability of pesticide dissipation half-lives in plants. Environ Sci Technol 47(8):3548–3556CrossRefGoogle Scholar
  11. Fantke P, Friedrich R, Jolliet O (2012) Health impact and damage cost assessment of pesticides in Europe. Environ Int 49:9–17CrossRefGoogle Scholar
  12. Fu Y, Zheng Z, Wei P, Wang M, Zhu G, Liu Y (2016) Distribution of thifluzamide, fenoxanil and tebuconazole in rice paddy and dietary risk assessment. Toxicol Environ Chem 98(1):118–127CrossRefGoogle Scholar
  13. Gillespie WE, Czapar GF, Hager AG (2011) Pesticide fate in the environment: a guide for field inspectors. Illinois State Water Survey Contract ReportGoogle Scholar
  14. Gupta S, Gajbhiye VT (2004a) Adsorption-desorption, persistence and leaching behavior of thifluzamide in alluvial soil. Chemosphere 57(6):471–480CrossRefGoogle Scholar
  15. Gupta S, Gajbhiye VT (2004b) Multiresidue method for the analysis of 25 selected pesticides in basmati rice. Pestic Res J 16(2):43–51Google Scholar
  16. Habtemariam S (1998) Extract of corn silk (Stigma of Zea mays) inhibits the tumour necrosis factor-alpha- and bacterial lipopolysaccharide-induced cell adhesion and icam-1 expression. Planta Med 64:314–318CrossRefGoogle Scholar
  17. Hoskins WM (1961) Mathematical treatment of the rate of loss of pesticide residues. FAO Plant Prot Bull 9:163–169Google Scholar
  18. Inoue T, Nagatomi Y, Suga K, Uyama A, Mochizuki N (2011) Fate of pesticides during beer brewing. J Agric Food Chem 59(8):3857–3868CrossRefGoogle Scholar
  19. Jung H, Sohn KD, Neppolian B, Choi H (2008) Effect of soil organic matter (SOM) and soil texture on the fatality of indigenous microorganisms in intergrated ozonation and biodegradation. J Hazard Mater 150(3):809–817CrossRefGoogle Scholar
  20. Kitagawa Y, Okihashi M, Takatori S, Okamoto Y, Fukui N, Murata H (2009) Multiresidue method for determination of pesticide residues in processed foods by GC/MS. Shokuhin Eiseigaku Zasshi 50(5):243–252CrossRefGoogle Scholar
  21. Konatu FRB, Breitkreitz MC (2017) Revisiting quick, easy, cheap, effective, rugged, and safe parameters for sample preparation in pesticide residue analysis of lettuce byliquid chromatography–tandem mass spectrometry. J Chromatogr A 1482:11–22CrossRefGoogle Scholar
  22. Lee KG, Jo EK (2012) Multiresidue pesticide analysis in Korean ginseng by gas chromatography–triple quadrupole tandem mass spectrometry. Food Chem 134:2497–2503CrossRefGoogle Scholar
  23. Li SJ (2017) The production and marketing pattern and its evolution of World corn dissertation. China Grain Econ 8:30–36Google Scholar
  24. Li RJ, Liu TJ, Song GC, Zhao Y, Cui SH, Yu JL (2017a) Residue and application safety assessment of thifluzamidein peanut and soil. Agrochemicals 56(5):357–360Google Scholar
  25. Li RJ, Liu TJ, Cui SH, Zhang SC, Yu JL, Song GC (2017b) Residue behaviors and dietary risk assessment of dinotefuran and its metabolites in Oryza sativa by a new HPLC-MS/MS method. Food Chem 235:188–193CrossRefGoogle Scholar
  26. Liu CY, Lu DH, Wang YC, Huang JX, Wan K, Wang FH (2014) Residue and risk assessment of pyridaben in cabbage. Food Chem 149:233–236CrossRefGoogle Scholar
  27. Liu YH, Shen DY, Li SL, Ni ZL, Ding M, Ye CF, Tang FB (2016) Residue levels and risk assessment of pesticides in nuts of China. Chemosphere 144:645–651CrossRefGoogle Scholar
  28. López-fernández O, Rialotero R, Simalgándara J, Boned J (2016) Dissipation kinetics of pre-plant pesticides in greenhouse-devoted soils. Sci Total Environ 543(Pt A):1–8CrossRefGoogle Scholar
  29. Lozowicka B, Kaczynski P, Paritova AE, Kuzembekova GB, Abzhalieva AB, Sarsembayeva NB, Alihan K (2014) Pesticide residues in grain from Kazakhstan and potential health risks associated with exposure to detected pesticides. Food Chem Toxicol 64:238–248CrossRefGoogle Scholar
  30. Malhat F, Badawy H, Barakat D, Saber A (2013) Determination of etoxazole residues in fruits and vegetables by SPE clean-up and HPLC-DAD. J Environ Sci Health 48(5):331–335CrossRefGoogle Scholar
  31. O’Reilly P, Kobayashi S, Yamane S, Phillips WG, Raymond P (1992) Mon 24000: a novel fungicide with broad-spectrum disease control. Pests and Diseases 1:427–434Google Scholar
  32. Pesticide Properties Database (PPDB) (2017) Thifluzamide (Ref: MON 24000). http://sitem.herts.ac.uk/aeru/iupac/Reports/1209.html. Accessed 30 Dec 2017
  33. Qin X, Sun Y, Xu YM, Wang Q, Yao JG, Gao Y (2013) Residue determination and degradation of thifluzamide in potato and soil. J Agric Resour Environ 30(6):83–86Google Scholar
  34. Reiler E, Jørs E, Bælum J, Huici O, Alvarez Caero MM, Cedergreen N (2015) The influence of tomato processing on residues of organochlorine and organophosphate insecticides and their associated dietary risk. Sci Total Environ 527–528:262–269CrossRefGoogle Scholar
  35. Rejeb SB, Cleroux C, Lawrence JF, Geay PY, Wu S, Stavinski S (2001) Development and characterization of immunoaffinity columns for the selective extraction of a new developmental pesticide: thifluzamide, from peanuts. Anal Chim Acta 432:193–200CrossRefGoogle Scholar
  36. Saber AN, Malhat FM, Badawy HMA, Barakat DA (2016) Dissipation dynamic, residue distribution and processing factor of hexythiazox in strawberry fruits under open field condition. Food Chem 196:1108–1116CrossRefGoogle Scholar
  37. Shi HY, Qi YJ, Shu ZL, Miu K, Zheng ZY, Wang MH (2016) Degradation adsorption-desorption and mobility characteristics of hexythiazox in soil. Eco Environ Sci 25(11):1806–1812Google Scholar
  38. Tewary DK, Kumar V, Ravindranath SD, Shanker A (2005) Dissipation behavior of bifenthrin residues in tea and its brew. Food Control 16:231–237CrossRefGoogle Scholar
  39. The Japan Food Chemical Research Foundation (2012) Table of MRLs for Agricultural Chemicals. http://www.m5.ws001.squarestart.ne.jp/foundation/agrdtl.php?a_inq=65-450. Accessed 30 Dec 2017
  40. Wang PD, Rashid MH, Liu J, Hu MY, Zhong GH (2016) Identification of multi-insecticide residues using GC-NPD and the degradation kinetics of chlorpyrifos in sweet corn and soils. Food chem 212:420–426CrossRefGoogle Scholar
  41. Wei LN, Wu P, Wang FR, Yang H (2015) Dissipation and degradation dynamics of thifluzamide in rice Field. Water Air Soil Pollut 226:130CrossRefGoogle Scholar
  42. Zhang ZD, Hui GQ, Zhang HM, Li Z, He XF (2006) Development of nutrition and value of medicine on maize. J Maize Sciences 14(3):173–176Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Food Science and Technology, Grain CollegeHenan University of TechnologyZhengzhouPeople’s Republic of China
  2. 2.Institute of Quality Standards and Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijingPeople’s Republic of China

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