Advertisement

Environmental Science and Pollution Research

, Volume 25, Issue 17, pp 17168–17175 | Cite as

Serum folate and cobalamin levels and urinary dimethylarsinic acid in US children and adults

  • Jianmin Zhu
  • Yanhui Gao
  • Dianjun Sun
  • Yudan Wei
Research Article

Abstract

Nutritional status could affect arsenic metabolism and toxicity in the general population chronically exposed to low levels of inorganic arsenic. In this study, we examined the association of serum folate and cobalamin with urinary concentrations of dimethylarsinic acid (DMA), the most abundant metabolite of inorganic arsenic measured in urine, in children and adults who participated in the 2003–2006 US National Health and Nutrition Examination Surveys. A total of 1161 children (aged 6–19 years) and 1938 adults (aged 20–85 years) were analyzed for the association using multivariate general linear models, adjusting for potential confounders. We observed a positive association between serum levels of folate and cobalamin and creatinine-corrected urinary concentrations of DMA in both children and adults. Furthermore, serum levels of folate and cobalamin were inversely associated with homocysteine (Hcy). These results suggest that dietary intake of folate and cobalamin may exhibit protective functions against arsenic toxicity by increasing arsenic metabolism to the less toxic metabolite DMA and decreasing serum levels of Hcy.

Keywords

Arsenic metabolism Cobalamin Folate Homocysteine Urinary dimethylarsinic acid 

Notes

Compliance with ethical standards

All procedures were approved by the NCHS Research Ethics Review Board, and all participants provided written informed consents.

Conflict of interest

The authors declare that they have no conflicts of interest.

References

  1. Ahsan H, Chen Y, Parvez F, Zablotska L, Argos M, Hussain I, Momotaj H, Levy D, Cheng Z, Slavkovich V, van Geen A, Howe GR, Graziano JH (2006) Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am J Epidemiol 163:1138–1148CrossRefGoogle Scholar
  2. Brauner EV, Nordsborg RB, Andersen ZJ, Tjonneland A, Loft S, Raaschou-Nielsen O (2014) Long-term exposure to low-level arsenic in drinking water and diabetes incidence: a prospective study of the diet, cancer and health cohort. Environ Health Perspect 122:1059–1065Google Scholar
  3. [CDC] Centers for Disease Control and Prevention (2004) Laboratory procedure manual (Method No: ITU003B). https://wwwn.cdc.gov/nchs/data/nhanes/2005-2006/labmethods/l06uas_d_met_arsenic_speciated.pdf. Accessed 8 June 2016
  4. [CDC] Centers for Disease Control and Prevention (2016a) National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/nhanes/nhanes_questionnaires.htm. Accessed 8 June 2016
  5. [CDC] Centers for Disease Control and Prevention (2016b) National health and nutrition examination survey: specifying weighting parameters. http://www.cdc.gov/nchs/tutorials/nhanes/surveydesign/Weighting/intro.htm. Accessed 27 June 2016
  6. [CDC] Centers for Disease Control and Prevention (2017) Lab methods. https://wwwn.cdc.gov/nchs/nhanes/continuousnhanes/labmethods.aspx?BeginYear=2005. Accessed 15 July 2017
  7. Chattopadhyay S, Deb B, Maiti S (2012) Hepatoprotective role of vitamin B12 and folic acid in arsenic intoxicated rats. Drug Chem Toxicol 35:81–88CrossRefGoogle Scholar
  8. Chen Y, Wu F, Liu M, Parvez F, Slavkovich V, Eunus M, Ahmed A, Argos M, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Graziano J, Ahsan H (2013) A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh. Environ Health Perspect 121:832–838CrossRefGoogle Scholar
  9. Davis MA, Mackenzie TA, Cottingham KL, Gilbert-Diamond D, Punshon T, Karagas MR (2012) Rice consumption and urinary arsenic concentrations in U.S. children. Environ Health Perspect 120:1418–1424CrossRefGoogle Scholar
  10. Feseke SK, St-Laurent J, Anassour-Sidi E, Ayotte P, Bouchard M, Levallois P (2015) Arsenic exposure and type 2 diabetes: results from the 2007–2009 Canadian Health Measures Survey. Health Promot Chronic Dis Prev Can 35:63–72CrossRefGoogle Scholar
  11. Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich V, Parvez F, Chen Y, Levy D, Factor-Litvak P, Graziano JH (2006) Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr 84:1093–1101CrossRefGoogle Scholar
  12. Hall MN, Liu X, Slavkovich V, Ilievski V, Pilsner JR, Alam S, Factor-Litvak P, Graziano JH, Gamble MV (2009a) Folate, cobalamin, cysteine, homocysteine, and arsenic metabolism among children in Bangladesh. Environ Health Perspect 117:825–831CrossRefGoogle Scholar
  13. Hall MN, Liu X, Slavkovich V, Ilievski V, Mi Z, Alam S, Factor-Litvak P, Ahsan H, Graziano JH, Gamble MV (2009b) Influence of cobalamin on arsenic metabolism in Bangladesh. Environ Health Perspect 117:1724–1729CrossRefGoogle Scholar
  14. Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman DA, Moore LE (1996) Methylation study of a population environmentally exposed to arsenic in drinking water. Environ Health Perspect 104:620–628CrossRefGoogle Scholar
  15. Howe CG, Niedzwiecki MM, Hall MN, Liu X, Ilievski V, Slavkovich V, Alam S, Siddique AB, Graziano JH, Gamble MV (2014) Folate and cobalamin modify associations between S-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. J Nutr 144:690–697CrossRefGoogle Scholar
  16. Huang YK, Huang YL, Hsueh YM, Yang MH, Wu MM, Chen SY, Hsu LI, Chen CJ (2008) Arsenic exposure, urinary arsenic speciation, and the incidence of urothelial carcinoma: a twelve-year follow-up study. Cancer Causes Control 19:829–839CrossRefGoogle Scholar
  17. Kordas K, Queirolo EI, Manay N, Peregalli F, Hsiao PY, Lu Y, Vahter M (2016) Low-level arsenic exposure: nutritional and dietary predictors in first-grade Uruguayan children. Environ Res 147:16–23CrossRefGoogle Scholar
  18. Lambrou A, Baccarelli A, Wright RO, Weisskopf M, Bollati V, Amarasiriwardena C, Vokonas P, Schwartza J (2012) Arsenic exposure and DNA methylation among elderly men. Epidemiology 23:668–676CrossRefGoogle Scholar
  19. Lehotsky J, Petras M, Kovalska M, Tothova B, Drgova A, Kaplan P (2015) Mechanisms involved in the ischemic tolerance in brain: effect of the homocysteine. Cell Mol Neurobiol 35:7–15CrossRefGoogle Scholar
  20. Li Y, Gao Y, Zhao L, Wei Y, Feng H, Wang C, Wei W, Ding Y, Sun D (2012) Changes in serum thioredoxin among individuals chronically exposed to arsenic in drinking water. Toxicol Appl Pharmacol 259:124–132CrossRefGoogle Scholar
  21. Lopez-Carrillo L, Gamboa-Loira B, Becerra W, Hernandez-Alcaraz C, Hernandez-Ramirez RU, Gandolfi AJ et al (2016) Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. Environ Res 151:445–450CrossRefGoogle Scholar
  22. Majumdar S, Maiti A, Karmakar S, Das AS, Mukherjee S, Das D et al (2012) Antiapoptotic efficacy of folic acid and vitamin B12 against arsenic-induced toxicity. Environ Toxicol 27:351–363CrossRefGoogle Scholar
  23. Moon KA, Guallar E, Umans JG, Devereux RB, Best LG, Francesconi KA, Goessler W, Pollak J, Silbergeld EK, Howard BV, Navas-Acien A (2013) Association between exposure to low to moderate arsenic levels and incident cardiovascular disease. A prospective cohort study. Ann Intern Med 159:649–659Google Scholar
  24. Mukherjee AK, Manna SK, Roy SK, Chakraborty M, Das S, Naskar JP (2016) Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India. J Environ Sci Health A Toxicol Hazard Subst Environ Eng 51:962–973CrossRefGoogle Scholar
  25. Pace C, Banerjee TD, Welch B, Khalili R, Dagda RK, Angermann J (2016) Monomethylarsonous acid, but not inorganic arsenic, is a mitochondria-specific toxicant in vascular smooth muscle cells. Toxicol in Vitro 35:188–201CrossRefGoogle Scholar
  26. Peters BA, Hall MN, Liu X, Parvez F, Sanchez TR, van Geen A, Mey JL, Siddique AB, Shahriar H, Uddin MN, Islam T, Balac O, Ilievski V, Factor-Litvak P, Graziano JH, Gamble MV (2015) Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial. Environ Health Perspect 123:1294–1301CrossRefGoogle Scholar
  27. Pierce BL, Tong L, Argos M, Gao J, Farzana J, Roy S et al (2013) Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction. Int J Epidemiol 42:1962–1971CrossRefGoogle Scholar
  28. Signes-Pastor AJ, Viogue J, Navarrete-Munoz EM, Carey M, Garcia de la Hera M, Sunyer J et al (2017) Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environ Res 159:69–75CrossRefGoogle Scholar
  29. Spratlen MJ, Gambel MV, Grau-Perez M, Kuo CC, Best LG, Yracheta J et al (2017) Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: evidence from the Strong Heart Study. Food Chem Toxicol 105:387–397CrossRefGoogle Scholar
  30. Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ (2002) The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ Health Perspect 110:767–771CrossRefGoogle Scholar
  31. Vahter ME (2007) Interactions between arsenic-induced toxicity and nutrition in early life. J Nutr 137:2798–2804CrossRefGoogle Scholar
  32. Wei Y, Zhu J, Nguyen A (2014) Rice consumption and urinary concentrations of arsenic in U.S. adults. Int J Environ Health Res 24:459–470CrossRefGoogle Scholar
  33. Yao Y, Shang MS, Dong JZ, Ma CS (2017) Homocysteine in non-valvular atrial fibrillation: role and clinical implications. Clin Chim Acta 475:85–90CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jianmin Zhu
    • 1
  • Yanhui Gao
    • 2
  • Dianjun Sun
    • 2
  • Yudan Wei
    • 3
  1. 1.Department of Mathematics and Computer ScienceFort Valley State UniversityFort ValleyUSA
  2. 2.Center for Endemic Disease Control, Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbinChina
  3. 3.Department of Community MedicineMercer University School of MedicineMaconUSA

Personalised recommendations