Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats
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Bisphenol A (BPA) is a widely used environmental pollutant in the production of plastics but causes hepatotoxicity in mammals. In the present study, we studied the BPA-induced oxidative stress in rats and ameliorative potential of Adiantum capillus-veneris L. plant. It was concluded that the BPA can reduce the body and liver weight, increase in biochemical levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total bilirubin, and disturb the normal hepatic physiology, histology, and metabolism. Additionally, liver histology shows hepatic necrosis, congestion, and vacuolization in exposed individuals. In contrast, simultaneous exposure of A. capillus-veneris and BPA showed declining trend in serum biomarker levels and normal histopathological structures. We conclude that the A. capillus-veneris plant is antioxidant in nature and can reduce the BPA-induced toxicity. These findings are very helpful to understand the BPA-induced hepatic toxicity and ameliorative potential of A. capillus-veneris plant and are of great importance in risk assessment of xenobiotics.
KeywordsA. capillus-veneris L. Bisphenol A (BPA) Hepatic injury Rats Restoration
Special thanks are given to the laboratory assistants for their help during experiment and analyses.
The authors greatly acknowledged the University of the Punjab for financial support for this study.
Compliance with ethical standards
The protocol of the study was approved by the departmental ethical committee of animal experiments, College of Earth and Environmental Sciences (CEES), University of the Punjab.
Conflict of interest
The authors declare that they have no conflict of interest.
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