Environmental Science and Pollution Research

, Volume 25, Issue 12, pp 11884–11892 | Cite as

Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats

  • Qudsia Kanwal
  • Abdul Qadir
  • Amina
  • Asmatullah
  • Hafiza Hira Iqbal
  • Bushra Munir
Research Article


Bisphenol A (BPA) is a widely used environmental pollutant in the production of plastics but causes hepatotoxicity in mammals. In the present study, we studied the BPA-induced oxidative stress in rats and ameliorative potential of Adiantum capillus-veneris L. plant. It was concluded that the BPA can reduce the body and liver weight, increase in biochemical levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total bilirubin, and disturb the normal hepatic physiology, histology, and metabolism. Additionally, liver histology shows hepatic necrosis, congestion, and vacuolization in exposed individuals. In contrast, simultaneous exposure of A. capillus-veneris and BPA showed declining trend in serum biomarker levels and normal histopathological structures. We conclude that the A. capillus-veneris plant is antioxidant in nature and can reduce the BPA-induced toxicity. These findings are very helpful to understand the BPA-induced hepatic toxicity and ameliorative potential of A. capillus-veneris plant and are of great importance in risk assessment of xenobiotics.


A. capillus-veneris L. Bisphenol A (BPA) Hepatic injury Rats Restoration 



Special thanks are given to the laboratory assistants for their help during experiment and analyses.

Funding information

The authors greatly acknowledged the University of the Punjab for financial support for this study.

Compliance with ethical standards

The protocol of the study was approved by the departmental ethical committee of animal experiments, College of Earth and Environmental Sciences (CEES), University of the Punjab.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Environmental Toxicology Laboratory, College of Earth and Environmental SciencesUniversity of the PunjabLahorePakistan
  2. 2.Developmental Biology Laboratory, Department of ZoologyUniversity of the PunjabLahorePakistan
  3. 3.University of Health SciencesLahorePakistan

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