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Comparison of high-intensity interval training and moderate-intensity continuous training in their effects on behavioral functions and CORT levels in streptozotocin-induced diabetic mice

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Abstract

Neurodegenerative disorders, such as deficits in cognition and motor coordination, are associated with diabetes mellitus (DM). It is believed that Corticosterone (CORT) has a role in behavioral functions. Exercise is beneficial on neurobehavioral impairment in DM; however, the debate about the value of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long-lasting. In the present study, we evaluated the effects of HIIT and MICT on cognitive performance, motor coordination, and serum CORT level using streptozotocin (STZ)–induced diabetes mice. We used STZ (50 mg/kg, i.p.) for five consecutive days to induce diabetes, followed by treatment with MICT and HIIT for 8 weeks. STZ-induced chronic diabetes significantly induced cognitive deficiency and motor coordination impairment in mice (p < 0.001). In addition, chronic diabetes significantly up-regulated CORT compared to controlled mice (p < 0.001). Chronic treatment with MICT and HIIT significantly reversed the diabetes-mediated motor coordination impairment and cognitive deficiency (p = 0.04 and p < 0.001 vs. STZ, respectively) by the adjustment of serum CORT level in diabetes mice (p = 0.037 and p = 0.001 vs. STZ, respectively). Also, it was found that HIIT significantly improved motor coordination compared to MICT (p = 0.043). There was also a significant negative correlation between serum CORT level and inhibitory avoidance (p = 0.012( and rotarod (p = 0.037) tests. Diabetes-mediated neurobehavioral impairment and the up-regulation of CORT substantially attenuated following MICT and HIIT treatment. However, HIIT might be more effective in diabetes-induced neurobehavioral impairment.

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  1. Department of Sport Sciences, Razi University, Kermanshah, Iran

    Ayoob Sabaghi & Ali Heirani

  2. Department of Biology, Razi University, Kermanshah, Iran

    Namdar Yousofvand

  3. Medical Student in Islamic Azad University of Tehran, Tehran, Iran

    Sana Sabaghi

  4. Department of Physical Education and Sport Sciences, Esfahan University, Esfahan, Iran

    Fateme Sadeghi

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Sabaghi, A., Heirani, A., Yousofvand, N. et al. Comparison of high-intensity interval training and moderate-intensity continuous training in their effects on behavioral functions and CORT levels in streptozotocin-induced diabetic mice. Sport Sci Health 17, 119–126 (2021). https://doi.org/10.1007/s11332-020-00661-3

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