Impact of severe OSA on pharmacoinvasive treatment in ST elevation myocardial infarction patients



The negative association between obstructive sleep apnea (OSA) and adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) is well documented. However, little is known about the influence of OSA on fibrinolytic therapy. The aim of this study was to evaluate the impact of severe OSA on pharmacoinvasive treatment in ST elevation myocardial infarction (STEMI) patients.


We enrolled consecutive STEMI patients without previous vascular disease, heart failure, or OSA diagnosis. All patients underwent either a pharmacoinvasive therapy or primary PCI. Syntax score (SS) was calculated for all patients, and a full bedside polysomnography was performed in the first 72 h of admission. In-hospital events and 30 days readmissions were analyzed.


The sample included 116 patients, 87 men. Patients with severe OSA were older (p = 0.01), had higher neck and abdominal circumferences (p < 0.01), and had higher BMI (p < 0.01). They also had lower reperfusion rates post-fibrinolysis (20 vs. 65%; p = 0.001), higher SS (20.2 ± 11.2 vs. 14.6 ± 10.6; p = 0.03), lower left ventricle ejection fraction (45 ± 8 vs. 51 ± 10%; p = 0.02), and a higher incidence of atrial arrhythmias (4 vs. 21%; p = 0.02). STEMI patients with severe OSA presented with threefold increase in the risk for at least one adverse outcome. Regression analysis showed that both severe OSA and hypertension were independent predictors of higher SS.


Severe OSA was associated with a poor outcome after pharmacoinvasive treatment in STEMI patients.

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This study was supported by the Associação Fundo de Incentivo à Pesquisa (AFIP), which provided personnel and the polysomnographic systems used during data collection.


This study was funded by the Associação Fundo de Pesquisa em psicofarmacologia (AFIP/2016).

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Correspondence to Fatima Cintra.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Maroja, F., Caixeta, A., Poyares, D. et al. Impact of severe OSA on pharmacoinvasive treatment in ST elevation myocardial infarction patients. Sleep Breath 24, 1357–1363 (2020).

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  • Obstructive sleep apnea
  • Fibrinolysis
  • Acute coronary syndrome