Abstract
Introduction
Although several studies suggested that sleep-related breathing disorder (SRBD) is a frequent symptom of multiple system atrophy (MSA), whether SRBD has influence on the motor and non-motor symptoms of MSA is unknown.
Methods
A total of 40 MSA patients and 40 healthy volunteers (HVs) underwent video-polysomnography (PSG) in the current study. All the MSA individuals were assessed using the Epworth Sleepiness Scale (ESS), Unified Multiple-System Atrophy Rating Scale (UMSARS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale, Frontal assessment battery (FAB), Parkinson’s Disease Questionnaire-39 (PDQ-39), and the Montreal Cognitive Assessment (MoCA).
Results
We found apnea-hypopnea index (AHI) of the MSA patients recorded by PSG was 16.4 ± 20.2. SRBD was found in 65% of the MSA patients (26/40), which was significantly higher than HVs (8/40, 20%) (p = 0.0001). Compared to the MSA patients without SRBD, MSA individuals with SRBD showed higher total UMSARS, UMSARS-II, FAB, and HAMD scores, more frequent occurrence of excessive daytime sleepiness, hypopneas, longer mean times for hypopneas, and obstructive sleep apnea (OSA), as well as longer time for OSA. This study suggested that SRBD is frequently seen in MSA patients.
Conclusion
MSA individuals with SRBD are prone to be severe motor deficits, depression, frontal lobe dysfunction, and excessive daytime sleepiness.
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Funding
Sichuan University provided financial support in the form of Young scholars’ scientific research funding (Grant No.2016SCU11017). The sponsor had no role in the design or conduct of this research.
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Contributions
Bei Cao: Clinical data collection, data analysis, and writing this paper;
Qian-Qian Wei: Clinical data collection and following up;
Ruwei Ou: Clinical data collection and following up;
Bi Zhao: Clinical data collection and following up;
Tao Hu: Clinical data collection and following up;
Yongping Chen: Clinical data collection and following up;
Jing Yang: Clinical data collection and following up;
Fei Lei: Data collection of sleep study;
Xiangdong Tang: Explaining the data of sleep study;
Hui-Fang Shang: Designing this study and revising this paper.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of Sichuan University research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Ethics Committee of Sichuan University approved this study. Informed consent was obtained from all individual participants included in the study.
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Cao, B., Wei, QQ., Ou, R. et al. Impact of sleep-related breathing disorder on motor and non-motor symptoms in multiple system atrophy. Sleep Breath 22, 981–987 (2018). https://doi.org/10.1007/s11325-018-1632-8
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DOI: https://doi.org/10.1007/s11325-018-1632-8