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Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain

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Abstract

Purpose

The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography ([18F]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats.

Procedures

Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [18F]FDG to measure the glucose metabolism during DBS.

Results

Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures.

Conclusions

This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [18F]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.

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Acknowledgments

This work is funded by iMinds and Ghent University. Prof. Dr. Roel Van Holen is supported by the Research Foundation, Flanders, Belgium (FWO). Prof. Dr. Christian Vanhove is supported by the GROUP-ID consortium of Ghent University. Prof. Dr. P. Boon is supported by grants from FWO and grants from BOF and by the Clinical Epilepsy Grant from Ghent University Hospital.

Conflict of Interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Medical Image and Signal Processing Group, Medical IT Department, Ghent University–iMinds, Ghent, Belgium

    Nathalie Van Den Berge, Vincent Keereman, Christian Vanhove, Pieter van Mierlo & Roel Van Holen

  2. Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University Hospital, Ghent, Belgium

    Bregt Van Nieuwenhuyse, Robrecht Raedt, Kristl Vonck & Paul Boon

Authors
  1. Nathalie Van Den Berge
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  2. Vincent Keereman
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  3. Christian Vanhove
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Correspondence to Nathalie Van Den Berge.

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Van Den Berge, N., Keereman, V., Vanhove, C. et al. Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain. Mol Imaging Biol 17, 373–383 (2015). https://doi.org/10.1007/s11307-014-0801-9

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