Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value

Abstract

Objectives

The aim of this study was to investigate of salivary gland dysfunction with single-photon emission computed tomography/computed tomography (SPECT/CT), especially the relationship between maximum standardized uptake value (SUVmax) of salivary glands and their dysfunction.

Methods

Five patients (2 submandibular sialolithiasis, 2 Sjögren's syndrome, and 1 parotitis) who underwent SPECT/CT were included in this study. The salivary gland excretion function was defined as A (pre-stimulatory 20 min after injection of Tc-99m pertechnetate)/B (post-stimulatory 40 min after injection of Tc-99m pertechnetate) using SUVmax of parotid and submandibular glands.

Results

SUVmax before stimulation of the submandibular gland with sialoliths in a patient was lower than that in the opposite submandibular gland without sialoliths (5.81 vs 51.37). Furthermore, the A/B using SUVmax in the other patient of submandibular glands with sialoliths was lower than that in the opposite submandibular glands without sialoliths (0.70 vs 1.85). The A/B using SUVmax of right and left parotid gland in a patient with Sjögren's syndrome was 1.06 and 0.74, respectively. Furthermore, the A/B using SUVmax of right and left parotid glands in the other patient with Sjögren's syndrome was 3.20 and 4.32, respectively. The A/B using SUVmax of right and left parotid glands in a patient with left parotitis was 2.26 and 1.58, respectively.

Conclusion

The results of the present study indicate that SUVmax using SPECT/CT seems a useful tool for evaluation of the salivary gland dysfunction.

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Fig. 1

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP 18K09754.

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Correspondence to Ichiro Ogura.

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Kazunori Ninomiya, Shuji Toya, and Ichiro Ogura declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

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Informed consent was obtained from all patients for being included in the study.

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Ninomiya, K., Toya, S. & Ogura, I. Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value. Oral Radiol 36, 163–167 (2020). https://doi.org/10.1007/s11282-019-00393-2

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Keywords

  • SPECT/CT
  • Salivary gland
  • Sialolithiasis
  • Parotitis
  • Sjögren's syndrome