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Retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab for carcinoma of the buccal mucosa with N3 lymph node metastasis: a case report

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Abstract

We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases. The patient responded well to the therapy, with a complete response of the primary tumor. Radical neck dissection was performed with reconstructive surgery, including resection of the overlying skin. A pathologic complete response was achieved for the N3 and all other cervical lymph node metastases. The patient showed no evidence of recurrence in the 3 years following treatment. Based on the findings in the present case, the use of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab seems to be a promising modality for patients with N3 cervical lymph node metastasis of oral cancer.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Kaname Sakuma, Toshiyuki Koizumi, Kenji Mitsudo, Yuichiro Hayashi, Toshinori Iwai, Makoto Hirota, Mitomu Kioi, Haruka Yoshii & Iwai Tohnai

  2. Department of Oral and Maxillofacial Surgery, Niigata Hospital, The Nippon Dental University, 1-8 Hamauracho, Chuo-ku, Niigata, 951-8580, Japan

    Kaname Sakuma & Jun Ueda

  3. Department of Radiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Hisashi Kaizu & Masaharu Hata

  4. Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamauracho, Chuo-ku, Niigata, 951-8580, Japan

    Akira Tanaka

Authors
  1. Kaname Sakuma
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  2. Toshiyuki Koizumi
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  3. Kenji Mitsudo
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  4. Jun Ueda
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  11. Masaharu Hata
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  12. Akira Tanaka
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  13. Iwai Tohnai
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Corresponding author

Correspondence to Toshiyuki Koizumi.

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Conflict of interest

Kaname Sakuma, Toshiyuki Koizumi, Kenji Mitsudo, Jun Ueda, Yuichiro Hayashi, Toshinori Iwai, Makoto Hirota, Mitomu Kioi, Haruka Yoshii, Hisashi Kaizu, Masaharu Hata, Akira Tanaka and Iwai Tohnai declare that they have no conflict of interest.

Human rights statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

Informed consent

Informed consent was obtained from the patient for being included in the study. The patient provided permission for his photographs to be published.

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Sakuma, K., Koizumi, T., Mitsudo, K. et al. Retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab for carcinoma of the buccal mucosa with N3 lymph node metastasis: a case report. Oral Radiol 35, 77–83 (2019). https://doi.org/10.1007/s11282-018-0319-y

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  • DOI: https://doi.org/10.1007/s11282-018-0319-y

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