Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome
Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.
KeywordsHPV Persistent infection Type III IFN Single-nucleotide polymorphisms IFN lambda 4
FC, AP, GA, and CS participated in the design of the study. FC and MS carried out genotyping test for IFNL4 polymorphism. FC and IL carried out PCR for HPV detection. IL collected the clinical data. NR and GdE collected the clinical samples. FC, AP, and CS wrote the manuscript. All authors read and approved the final manuscript.
This study was funded by a Grant to Alessandra Pierangeli from Sapienza University of Rome (Ricerche Universitarie, anno 2015, Number of Grant: C26A199B4 N).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethics committee of the Policlinico Umberto I Hospital, ‘‘Sapienza’’ University of Rome.
Informed consent was obtained from all individual participants included in the study.
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