Abstract
This study was aimed to compare the effects of intratesticular (IT) and intramuscular (IM) administration of the zolazepam-tiletamine (ZT) combination on sedation, induction, and recovery qualities and vital variables in cats undergoing castration. Fourteen clinically client-owned healthy cats were randomly assigned to receive 10 mg/kg ZT by either IT or IM routes. Temperament score, injection reaction score, induction time, intubation time, surgical length, anesthesia time, recovery time, and full recovery time were evaluated. Sedation score, heart rate (HR), respiratory frequency (fR), peripheral hemoglobin oxygen saturation (SpO2), mean arterial pressure (MAP), and rectal temperature (RT) variables were assessed at baseline (T0), T5, T10, T15, and T30. Median temperament score and injection reaction score were not different between groups. Induction time was significantly (p = 0.0244) shorter for the IT group (142.6 ± 29.9) than IM (290 ± 48.7 seconds). Length of anesthesia was longer in the IM group (median 290; ranged 120–540 minutes) than the IT group (median 140; ranged 98–180 minutes) (p = 0.0279). Time to standing and time to full recovery were significantly shorter in IT than IM. A recovery quality score did not significantly differ between groups (p = 0.2268). No statistically significant differences were detected between IT and IM administration regarding sedation score, HR, SpO2, MAP, and RT. The IT administration of 10 mg/kg ZT induces shorter onset of sedation and recovery time than IM administration, thereby it can be suggested for cats undergoing castration. Both administration routes produce effective sedation with limited physiological changes in anesthesia variables.
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Bruniges N, Taylor PM, Yates D (2010) Injectable anaesthesia for adult cat and kitten castration: effects of medetomidine, dexmedetomidine and atipamezole on recovery. J Feline Med Surg 18:860–867
Deutsch J, Jolliffe C, Archer E et al (2017) Intramuscular injection of alfaxalone in combination with butorphanol for sedation in cats. Vet Anaesth Analg 44:794–802
Forsyth S (1995) Administration of a low dose tiletamine-zolazepam combination to cats. N Z Vet J 43:101–103
Hancock TM, Caulkett NA, Pajor EA, Grenwıch L (2018) An investigation of the effects of intratesticular alfaxalone and lidocaine during castration in piglets. Vet Anaesth Analg 45:858–864
Hellyer P, Muir WW, Hubbell JA, Sally J (1988) Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to cats. Vet Surg 17:105–110
Henry DP (1968) Anaesthesia of boars by intratesticular injection. Aust Vet J 44:418–419
Ilkiw JE (1992) Other potentially useful new injectable anesthetic agents. Vet Clin North Am Small Anim Pract 22:281–289
Kim JK, Jeong SM, Yi NY et al (2004) Effect of intratesticular injection of xylazine/ketamine combination on canine castration. J Vet Sci 5:151–156
Ko JC, Abbo LA, Weil AB (2007) A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in cats. Vet Ther 8:164–176
Kucharski P, Kiełbowicz Z (2021) Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it. Pol J Vet Sci 24:451–459
Lascelles BDX, Court MH, Hardie EM et al (2007) Nonsteroidal anti-inflammatory drugs in cats: a review. Vet Anaesth Analg 34:228–250
Lin HC, Thurmon JC, Benson GJ et al (1993) Telazol – a review of its pharmacology and use in veterinary medicine. J Vet Pharmacol Ther 16:383–418
Nejamkin P, Cavilla V, Clausse M et al (2019) Sedative and physiologic effects of tiletamine-zolazepam following buccal administration in cats. J Feline Med Surg 22:108–113
Pablo LS, Bailey JE (1999) Etomidate and telazol. Vet Clin North Am Small Anim Pract 29:779–792
Polson S, Taylor PM, Yates D (2012) Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial. J Feline Med Surg 14:553–559
Robertson S (2020) Anesthetic protocols for dogs and cats. In: White S. high-quality, high-volume spay and neuter and other shelter surgeries, 1st edn. Wiley-Blackwell, Iowa, pp 153–192
Short CE (1987) Dissociative anesthesia. In: Principles and practice of veterinary anesthesia. Williams & Wilkins, Baltimore, p 158
Steagall PV, Monteiro BP (2019) Acute pain in cats: recent advances in clinical assessment. J Feline Med Surg 21:25–34
Suburo AM, Chiocchio SR, Soler MVC et al (2002) Peptidergic innervation of blood vessels and interstitial cells in the testis of the cat. J Androl 23:121–134
Yanmaz LE, Dogan E, Okur S et al (2016) Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats. Vet Ophtalmol 19:115–118
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LEY: Literature search, statistical analysis, data collection and interpretation, manuscript preparation. SO: Literature search, study design, data collection and interpretation. UE: Literature search, study design, data collection and interpretation. MGS: Study design, data collection and interpretation. AG: Data collection and interpretation, manuscript preparation.
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All procedures involving animals were in compliance with the European Community Council Directive of 24 November 1986, and ethical approval was granted by the Atatürk University Animal Experiments Local Ethics Committee (No. 2022/11, Erzurum, Turkey).
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Yanmaz, L.E., Okur, S., Ersoz, U. et al. Comparison of intratesticular and intramuscular administration of zolazepam-tiletamine combination on sedation, induction, and recovery qualities and vital variables in cats undergoing castration: a prospective, randomized, clinical study. Vet Res Commun 46, 1349–1353 (2022). https://doi.org/10.1007/s11259-022-09993-6
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DOI: https://doi.org/10.1007/s11259-022-09993-6