Effectiveness of renal-specific oral nutritional supplements compared with diet counseling in malnourished hemodialysis patients

Abstract

Background

Malnutrition is highly prevalent and a consequence of inflammation and related comorbidities among patients on maintenance hemodialysis. Oral nutritional supplementation (ONS) is recommended for malnourished patients with kidney failure. The study aimed to evaluate renal-specific oral nutrition (ONCE dialyze) supplement on nutritional status in patients on hemodialysis.

Methods

Patients were randomized into 3 groups; treatment groups received 370 kcal/day of ONCE Dialyze (N = 26) or 370 kcal/day of NEPRO (N = 30) for 30 days. The control group (N = 24) received no intervention. All patients were counseled by the same registered dietitian during the study. The nutritional status was evaluated using malnutrition inflammation score (MIS) assessment, body compositions, serum albumin and pre-albumin levels at baseline and 30 days.

Results

Eighty patients were analyzed with mean age of 57.2 ± 15.9 years. The intervention group exhibited significant improvements in energy, protein, fat, fiber and magnesium intake by dietary interview compared with the control group. Percentage of changes in MIS was − 29.0% (95% CI − 40.5 to − 17.4), − 23.9% (95% CI − 37.2 to − 10.6) and 12.1% (95% CI − 19.2 to 43.4) for the ONCE dialyze, NEPRO and control groups, respectively (overall P = 0.006). Percentage of changes in serum albumin was 5.3% (95% CI 1.9–8.7), 3.3% (95% CI − 0.1 to 6.7) and − 0.8% (95% CI − 4.3 to 2.7) for the ONCE dialyze, NEPRO, and control groups, respectively (overall P = 0.039; P = 0.043 for ONCE dialyze vs. control). No serious adverse effects were reported in any group.

Conclusion

Dietary advice combined with ONS especially ONCE dialyze was associated with improved MIS, serum albumin, dietary energy and macronutrient intake among patients with kidney failure on maintenance hemodialysis.

Clinical trial registration

TCTR20200801001.

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Data availability

Data supporting this study are available upon request.

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Acknowledgements

The authors wish to acknowledge the contributions of the following individuals to this study: staff in the Division of Nephrology in Phramongkutklao Hospital.

Funding

The study was supported by a Grant from Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand and the Thai Otsuka Pharmaceutical Co., Ltd. Thailand, which had no influence on the design, conduct, analysis or reporting of our trial.

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Correspondence to Bancha Satirapoj.

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The study was approved by the Ethics Committee of the Institute Review Board at the Royal Thai Army Medical Department and was conducted according to the Declaration of Helsinki.

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Informed consent was obtained from all participants.

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Limwannata, P., Satirapoj, B., Chotsriluecha, S. et al. Effectiveness of renal-specific oral nutritional supplements compared with diet counseling in malnourished hemodialysis patients. Int Urol Nephrol (2021). https://doi.org/10.1007/s11255-020-02768-5

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Keywords

  • Renal-specific oral nutrition
  • Maintenance hemodialysis
  • Serum albumin
  • Nutrition status