Survival outcomes of Asian younger men (< 55 years) undergoing radical prostatectomy: a review of prostate cancer database in a tertiary hospital in Singapore

Abstract

Purpose

Prostate cancer largely affects older men. This study aims to investigate prostate cancer in younger men (< 55 years) to shed light on the survival outcomes of this unique subset of patients in Asian context.

Methods

Data were obtained from the Singapore General Hospital Prostate Cancer Registry. Data on all men with clinically organ confined prostate cancer who underwent radical prostatectomy between 1998 and 2016 were obtained from the registry. Tumor characteristics, follow-up data, and cause of death were acquired.

Results

A total of 1120 men underwent radical prostatectomy between 1998 and 2016. Of these, 12 were aged ≤ 44 years, 106 were aged 45–54 years, 596 were aged 55–64, 397 were aged 65–74 and 9 were aged ≥ 75. There was no difference across age groups when comparing Gleason ≤ 7 vs Gleason ≥ 8 disease, T1/2 vs T3/4 disease and the median PSA values were similar. No difference was observed in overall survival or prostate cancer specific survival among 4 age groups (≤ 44, 45–54, 55–64, 65–74) (p = 0.156 and p = 0.227 respectively). Although there was a trend of increasing rate of biochemical recurrence for older patients, it’s not statistically significant (p = 0.157). Time to biochemical recurrence was similar as well (p = 0.257).

Conclusion

This large cohort of Asian patients who underwent radical prostatectomy did not show significant age-related differences in important parameters and outcomes.

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Acknowledgements

We would like to extend our gratitude to all staff who are involved in building and maintaining SGH Prostate Cancer Registry for their hard work and dedication.

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Authors

Contributions

All three authors contributed in study conception and design. YL and HHH contributed in data acquisition, data analysis, statistical analysis and interpretation. YL also contributed in drafting and revision of the manuscript. WKOL contributed in critical revision of the manuscript for important intellectual content as well as provided overall supervision of the study. All authors discussed the results and approved the final manuscript.

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Correspondence to Yadong Lu.

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Lu, Y., Huang, H.H. & Lau, W.K.O. Survival outcomes of Asian younger men (< 55 years) undergoing radical prostatectomy: a review of prostate cancer database in a tertiary hospital in Singapore. Int Urol Nephrol (2020). https://doi.org/10.1007/s11255-020-02518-7

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Keywords

  • Prostate cancer
  • Radical prostatectomy
  • Age groups
  • Survival outcome
  • Young men