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Functional capacity, renal function and vitamin D in community-dwelling oldest old

  • Nephrology - Original Paper
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Abstract

Purpose

The aim of this study was to evaluate the association between the decline in estimated glomerular filtration rate (eGFR) and serum 25(OH)D with the physical and mental functional capacity of elderly individuals aged 80 years or older.

Methods

We evaluated the functional capacity in its multidomain aspects: Geriatric Depression Scale (GDS), Instrumental Activities of Daily Living (IADL), Mental State Mini-Exam (MMSE), Verbal Fluency Test (VF), handgrip strength and time to sit and rise from a chair five times, combined creatinine and cystatin C-based eGFR and 25(OH)D levels in 205 independent asymptomatic and community-dwelling elderly subjects in a cross-sectional study.

Results

Every 1 year of life, there was reduction of about 10% chance of adequate performance in functional capacity. Each 1 ml/min/m2 in eGFR was associated with 2% better chance of adequate performance in the IADL. We found no association between eGFR and cognition. Serum 25(OH)D between 15.00 and 22.29 ng/ml increased the chance of better performance in VF, IADL, handgrip strength and sit and rise from the chair compared to the lower level of serum vitamin D.

Conclusions

Decreased renal function associated with age compromises the ability to perform activities for independent life in the community, but we did not observe influence in specific domains of cognition and physical performance. Low serum level of 25(OH)D appears to be a marker of greater risk of functional decline than eGFR measurement in independent oldest old dwelling in the community.

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Acknowledgements

This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (2011/12753-8).

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Authors and Affiliations

  1. Division of Geriatrics and Gerontology, School of Medicine, Federal University of São Paulo, Unifesp, Rua Professor Francisco de Castro, 105, São Paulo, SP, 04020-050, Brazil

    Lara Miguel Quirino Araujo, Patricia Ferreira do Prado Moreira, Clineu de Mello Almada Filho & Maysa Seabra Cendoroglo

  2. Information Systems, School of Arts, Sciences and Humanities, USP, São Paulo, Brazil

    Luciano Vieira de Araujo

  3. Division of Nephrology, School of Medicine, Unifesp, Federal University of São Paulo, São Paulo, Brazil

    Michelle Tiveron Passos, Gianna Mastroianni Kirsztajn, Miguel Cendoroglo Neto & Ricardo Castro Cintra Sesso

  4. Hospital Israelita Albert Einstein, Federal University of São Paulo, São Paulo, Brazil

    Miguel Cendoroglo Neto

Authors
  1. Lara Miguel Quirino Araujo
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  2. Patricia Ferreira do Prado Moreira
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Correspondence to Lara Miguel Quirino Araujo.

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Araujo, L.M.Q., Moreira, P.F.d., Almada Filho, C.d. et al. Functional capacity, renal function and vitamin D in community-dwelling oldest old. Int Urol Nephrol 51, 713–721 (2019). https://doi.org/10.1007/s11255-019-02081-w

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