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Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions

  • Urology - Original Paper
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Abstract

Objective

Traumatic brain injury (TBI) is a global scenario with high mortality and disability, which does not have an effectual and approved therapy till now. Bladder dysfunction is a major symptom after TBI, and this study deals with the alleviation of bladder function in TBI rats, with the aid of deep brain stimulations (DBS).

Methods

TBI was induced by weight drop model (WDM) and standardized with the experimental subjects with variable heights for weight dropping. The rats survived after TBI were considered for bladder dysfunction observations. DBS with variable stimulation parameters like cystometric analysis and MRI studies were also performed.

Results

After experimental studies, TBI 2-m-height crash was determined as suitable parameter due to minimal mortality rate and significant reduction in the voiding efficiency from 67 to 28%, whereas DBS significantly reversed the value of voiding efficiency to 65–84%. MRI studies revealed the severity of TBI impact and DBS localization.

Conclusion

The results showed profound therapeutic effect of PnO-DBS on voiding functions and bladder control on TBI rats.

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Acknowledgements

The experimental procedures used in the present study were approved by the Institutional Animal Care and Use Committee (IACUC) of Taipei Medical University (TMU) and followed by the TMU IACUC guidelines to treat animals humanely and reduce animal suffering by use of appropriate anaesthesia and analgesics (IACUC Approval No. LAC-2013-0199).

Funding

This work was supported by the Taiwan Ministry of Science and Technology under the Grant Number MOST106-2221-E-038-010-MY3 and MOST107-2811-E-038-001 to C.W. Peng.

Author information

Authors and Affiliations

  1. School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan

    Chellappan Praveen Rajneesh & Chih-Wei Peng

  2. Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Chien-Hung Lai, Shih-Ching Chen & Chih-Wei Peng

  3. Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan

    Chien-Hung Lai, Shih-Ching Chen & Chih-Wei Peng

  4. Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Tsung-Hsun Hsieh

  5. Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan

    Tsung-Hsun Hsieh

  6. Department of Obstetrics and Gynaecology, Taipei Medical University Hospital, Taipei, Taiwan

    Hung-Yen Chin

  7. Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Hung-Yen Chin

  8. Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan

    Chih-Wei Peng

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  1. Chellappan Praveen Rajneesh
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  4. Tsung-Hsun Hsieh
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Correspondence to Chih-Wei Peng.

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The authors report no conflicts of interest.

Ethical approval

This work was approved and conducted under the ethical guidance of Institutional Animal Care and Use Committee (IACUC) of Taipei Medical University (Approval No. LAC-2013-0199).

Research involving human and animal participants

This article does not contain any studies with human participants performed by any of the authors.

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Praveen Rajneesh, C., Lai, CH., Chen, SC. et al. Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions. Int Urol Nephrol 51, 41–52 (2019). https://doi.org/10.1007/s11255-018-2028-1

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  • DOI: https://doi.org/10.1007/s11255-018-2028-1

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