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Association between MCP-1 2518 A>G gene polymorphism and chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Monocyte chemoattractant protein-1 (MCP-1) is involved in the pathogenesis of chronic kidney diseases (CKD). MCP-1 2518 A>G gene polymorphism is associated with MCP-1 status. We performed a meta-analysis to assess the association between MCP-1 2518 A>G gene polymorphism and CKD risk. The eligible studies regarding the relationship between MCP-1 2518 A>G gene polymorphism and CKD risk were searched through electronic databases. The pooled odds ratios (ORs) and its 95% confidence intervals (CIs) were calculated by using a fixed-effects model, or in the presence of heterogeneity, a random-effects model. A total of 2415 cases and 2011 controls were recruited in our investigation. A allele/GG genotype was not associated with CKD risk in overall populations, Asians, Caucasians, and Africans. AA/AG genotype was not associated with the risk of CKD in overall populations, Asians, Caucasians, and Africans. AA genotype was associated with a lower risk of CKD in Caucasians (OR 0.816, 95% CI 0.703–0.947). AG genotype was associated with a higher risk of CKD in Caucasians (OR 1.230, 95% CI 1.042–1.452). There was no marked publication bias. In conclusion, AA genotype may be a protective factor against CKD susceptibility in Caucasians. AG genotype may be a risk factor for CKD risk in Caucasians. However, more studies are needed in the future.

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Acknowledgements

This study was supported by Grant from the National Natural Science Foundation of China (Grant Number 81600578) and weak discipline construction of Shanghai health and family planning commission (Grant Number 2016ZB0102-03).

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  1. Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

    Song Mao & Liangxia Wu

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  1. Song Mao
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Correspondence to Song Mao or Liangxia Wu.

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Mao, S., Wu, L. Association between MCP-1 2518 A>G gene polymorphism and chronic kidney disease. Int Urol Nephrol 50, 2245–2253 (2018). https://doi.org/10.1007/s11255-018-1955-1

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