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Sagittal abdominal diameter and Framingham risk score in non-dialysis chronic kidney disease patients

  • Nephrology - Original Paper
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Abstract

Background

Chronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that abdominal obesity is a risk factor for cardiovascular mortality. We investigated the link between sagittal abdominal diameter (SAD) and Framingham risk score in non-dialysis CKD patients.

Methods

In a cross-sectional study, we enrolled 307 prevalent non-dialysis CKD patients (175 males, aged 50.7 ± 17.04 years). SAD and Framingham risk score were measured.

Results

Framingham cardiovascular disease risk score was independently predicted by SAD (P < 0.01), GFR (P < 0.01) and diabetic history (P < 0.05). Adjusted R2 of the model was 0.178. SAD could be independently predicted by BMI (P < 0.01), diabetic history (P < 0.01), GFR (P < 0.01) and age (P < 0.01). Adjusted R2 of the model was 0.409. Using receiver operating characteristic (ROC) curve, a cutoff SAD value of 16.55 cm was determined with sensitivity of 63.7%, specificity of 58.3%.

Conclusion

Elevated SAD is significantly associated with increased Framingham risk score in non-dialysis CKD patients. SAD can be predicted by patients’ BMI, diabetic history, renal function and age. Further investigation is needed to explore the potential benefits of central obesity lowering therapy in this patient group.

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Acknowledgements

The authors thank all the patients and staff of the Division of Nephrology.

This work was funded by grant from Chinese Society of Blood Purification Administration (CHABP2016-07), was supported by Chinese Society of Nephrology Grant (13030310416) and was funded by Special Supporting Program for Young Teachers in Kunming Medical University.

BY was supported by a Grant from Graduate Innovation Fund in Kunming Medical University.

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Author notes

  1. Hua Xiao and Yu Bao contribute equally to this work.

Authors and Affiliations

  1. Division of Nephrology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan province, China

    Hua Xiao, Yu Bao, Yi-An Wang, Ying Wang, Yue Yan, Zhu Zhu, Mei Ni & Xing-Wei Zhe

  2. Division of Nephrology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

    Ming-Yue Liu

  3. Division of Nephrology, Puer People’s Hospital, Puer, Yunnan Province, China

    Jun-Hua Yang

  4. Intensive Care Unit, General Hospital of Ningxia Medical University, Yinchuan, China

    Yan-Ting Li

  5. Department of Nephrology, The First People’s Hospital of Xuzhou, Xuzhou, Jiangsu Province, China

    Xiao-Yan Huang

  6. Division of Nephrology, Peking University Third Hospital, Beijing, China

    Xin-Kui Tian & Tao Wang

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  1. Hua Xiao
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  2. Yu Bao
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Corresponding author

Correspondence to Xing-Wei Zhe.

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Xiao, H., Bao, Y., Liu, MY. et al. Sagittal abdominal diameter and Framingham risk score in non-dialysis chronic kidney disease patients. Int Urol Nephrol 50, 1679–1685 (2018). https://doi.org/10.1007/s11255-018-1861-6

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  • DOI: https://doi.org/10.1007/s11255-018-1861-6

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