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International Urology and Nephrology

, Volume 50, Issue 4, pp 733–743 | Cite as

Comparative evaluation of technetium-99m-diethylenetriaminepentaacetic acid renal dynamic imaging versus the Modification of Diet in Renal Disease equation and the Chronic Kidney Disease Epidemiology Collaboration equation for the estimation of GFR

  • Qi Huang
  • Yunshuang Chen
  • Min Zhang
  • Sihe Wang
  • Weiguang Zhang
  • Guangyan Cai
  • Xiangmei Chen
  • Xuefeng Sun
Nephrology - Original Paper

Abstract

Purpose

We compared the performance of technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA) renal dynamic imaging (RDI), the MDRD equation, and the CKD EPI equation to estimate glomerular filtration rate (GFR).

Methods

A total of 551 subjects, including CKD patients and healthy individuals, were enrolled in this study. Dual plasma sample clearance method of 99mTc-DTPA was used as the true value for GFR (tGFR). RDI and the MDRD and CKD EPI equations for estimating GFR were compared and evaluated.

Results

Data indicate that RDI and the MDRD equation underestimated GFR and CKD EPI overestimated GFR. RDI was associated with significantly higher bias than the MDRD and CKD EPI equations. The regression coefficient, diagnostic precision, and consistency of RDI were significantly lower than either equation. RDI and the MDRD equation underestimated GFR to a greater degree in subjects with tGFR ≥ 90 ml/min/1.73 m2 compared with the results obtained from all subjects. In the tGFR60-89 ml/min/1.73 m2 group, the precision of RDI was significantly lower than that of both equations. In the tGFR30-59 ml/min/1.73 m2 group, RDI had the least bias, the most precision, and significantly higher accuracy compared with either equation. In tGFR < 30 ml/min/1.73 m2, the three methods had similar performance and were not significantly different.

Conclusions

RDI significantly underestimates GFR and performs no better than MDRD and CKD EPI equations for GFR estimation; thus, it should not be recommended as a reference standard against which other GFR measurement methods are assessed. However, RDI better estimates GFR than either equation for individuals in the tGFR30-59 ml/min/1.73 m2 group and thus may be helpful to distinguish stage 3a and 3b CKD.

Keywords

Renal dynamic imaging (RDI) Glomerular filtration rate (GFR) Modification of Diet in Renal Disease (MDRD) equation Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation 

Notes

Funding

This work was supported by the grants from the Major State Basic Research Development Program of China (2013CB530800), National Natural Science Foundation of China (81270819), National Key Technology R&D Program (2011BAI10B00). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Qi Huang
    • 1
    • 2
  • Yunshuang Chen
    • 1
  • Min Zhang
    • 1
  • Sihe Wang
    • 3
  • Weiguang Zhang
    • 1
  • Guangyan Cai
    • 1
  • Xiangmei Chen
    • 1
  • Xuefeng Sun
    • 1
  1. 1.Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina
  2. 2.Department of NephrologyBeijing Tiantan Hospital, Capital Medical UniversityBeijingChina
  3. 3.Department of Clinical PathologyCleveland ClinicClevelandUSA

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