International Urology and Nephrology

, Volume 50, Issue 2, pp 231–236 | Cite as

Effects of statin treatment with atorvastatin on urolithiasis-associated urinary metabolic risk factors: an experimental study

  • Mustafa Zafer Temiz
  • Emrah Yuruk
  • Kasim Ertas
  • Oguzhan Zengi
  • Atilla Semercioz
Urology - Original Paper



To investigate whether atorvastatin has favorable effects on urinary metabolic risk factors associated with urolithiasis.


Sixteen male Sprague–Dawley rats were randomly divided into two groups, and baseline spot and 24-h urine samples were collected. Distilled water and atorvastatin were administered to rats during 4 weeks in the control and atorvastatin groups, respectively. At the end of the experimental procedure, spot and 24-h urine samples were collected again. Citrate, oxalate, cystine, uric acid, calcium and magnesium levels were determined in 24-h urine samples. Citrate/creatinine, oxalate/creatinine, uric acid/creatinine, calcium/creatinine and magnesium/creatinine ratios were also calculated in spot urine samples. Comparison of the baseline and post-experimental levels of these parameters was made in each group.


The majority of the parameters were similar before and after the experimental procedure in each group. In the atorvastatin group, uric acid and calcium levels were affected. Administration of atorvastatin was significantly decreased the levels of uric acid, whereas increased the levels of calcium (P = 0.025 and P = 0.017, respectively).


Our study revealed that atorvastatin has decreasing effect on UUa levels, whereas increasing effect on UCa levels. We think it cannot certainly be deduced that atorvastatin could be beneficial on overall urinary metabolic risk factors. Contrarily, atorvastatin may lead to an increased risk of calcium stones, but when considering its UUa decreasing effect, it may help in reducing the uric acid stone recurrence.


Statins Atorvastatin Urolithiasis Urine Risk factors 



We want to thank staffs of Experimental Animals Laboratory of Bagcilar Training and Research Hospital for their valuable supports during the experimental procedures.

Compliance with ethical standards

Conflict of interest

All authors declare to have no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • Mustafa Zafer Temiz
    • 1
  • Emrah Yuruk
    • 2
  • Kasim Ertas
    • 2
  • Oguzhan Zengi
    • 3
  • Atilla Semercioz
    • 2
  1. 1.Department of UrologyCatalca State HospitalCatalca, IstanbulTurkey
  2. 2.Department of UrologyBagcilar Training and Research HospitalIstanbulTurkey
  3. 3.Department of BiochemistryBagcilar Training and Research HospitalIstanbulTurkey

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