The objective of this study was to investigate the impacts of dietary supranutritional supplementation of selenium-yeast (SY) on growth performance, blood cells, antioxidant status, and metabolic profile of lambs. Twenty-one Kermani male lambs (28.5 ± 2.6 kg of body weight) were used in a completely randomized design for 8 weeks under warm condition with temperature-humidity index (THI) of 81.3 ± 0.37 unit. The lambs were randomly divided into 3 groups given the basal diet either un-supplemented (control group) or supplemented with 0.6 or 1.2 mg of Se/kg dry matter (DM) as SY. Average daily Se intake was 0.12, 0.83, and 1.54 mg in lambs on control, 0.6 mg and 1.2 mg of supplemental Se treatments, respectively (P < 0.0001). The results showed that average daily gain tended to be higher in lambs received Se-supplemented diets than those fed the unsupplemented diet (P < 0.1). Feed efficiency improved by SY supplementation, thereby feed to gain ratio (FG) reduced 19 and 17% respectively in lambs fed 0.6 (FG = 6.58) and 1.2 (FG = 6.7) mg of Se/kg DM compared to those of the control (FG = 8.12) (P < 0.05). Feeding 1.2 mg of Se to growing lambs not only improved blood total antioxidant capacity (T-AOC) as 18.1% and glutathione peroxidase activity (GSH-Px) as 17.6%, but also made 13.1% reduction in serum malondialdehyde (MDA) concentration as a lipid peroxidation marker (P < 0.05). Despite its statistical insignificance (P > 0.05), erythrocyte superoxide dismutase (SOD) activity was also greater in Se-fed groups compared to that of the control. Based on the obtained data, lambs fed 1.2 mg of Se/kg DM, had lower serum urea concentration and albumin to globulin ratio than those on unsupplemented diet (P < 0.05). Moreover, increased RBC count was observed in lambs received 0.6 mg of supplemental Se (P < 0.05). Selenium-enriched yeast supplementation gave rise to increased blood lymphocyte percentage (P < 0.05). The results also indicated that dietary high Se feeding had no adverse effects on blood metabolites including glucose, total protein, albumin, globulin, liver enzymes, and triglyceride content. In the overall, these findings suggest that Se-enriched yeast is a kind of safe Se source for sheep and its dietary supranutritional supplementation for 8 weeks improves feed efficiency of growing lambs. Furthermore, increasing the supplemental Se to 1.2 mg/kg of diet promotes lambs’ blood antioxidant status without inducing any detrimental impacts on cell metabolism.
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Ahsan, U., Kamran, Z., Raza, I., Ahmad, S., Babar, W. and Riaz, M.H., 2014. Role of selenium in male reproduction-A review. Animal Reproduction Science, 146, 55-62.
Alhidary, I.A., Shini, S., Al Jassim, R.A.M. and Gaughan, J. B., 2012. Effect of various doses of injected selenium on performance and physiological responses of sheep to heat load. Journal of Animal Science, 90, 2988-2994.
Alimohamady, R., Aliarabi, H., Bahari, A. and Dezfoulian, A.H., 2013. Influence of different amounts and sources of selenium supplementation on performance, some blood parameters, and nutrient digestibility in lambs. Biological Trace Element Research, 154, 45-54.
Association of Official Analytical Chemists (AOAC), 2000. Official methods of analysis, 17th ed. Published by AOAC international, Gaithersburg, Maryland, USA.
Chauhan, S.S., Ponnampalam, E.N., Celi, P., Hopkins, D.L., Leury, B.J. and Dunshea, F.R., 2016. High dietary vitamin E and selenium improves feed intake and weight gain of finisher lambs and maintains redox homeostasis under hot conditions. Small Ruminant Research, 137, 17-23.
Cobanova, K., Faix, S., Placha, I., Mihalikova, K., Varadyova, Z., Kisidayova, S. and Gresakova, L., 2017. Effects of different dietary selenium sources on antioxidant status and blood phagocytic activity in sheep. Biological Trace Element Research, 175, 339-346.
Dikeman, M.E., 2007. Effects of metabolic modifiers on carcass traits and meat quality. Meat Science, 77, 121-135.
Faixova, Z., Faix, S., Leng, L., Vaczi, P., Makova, Z. and Szaboova, R., 2007. Haematological, blood and rumen chemistry changes in lambs following supplementation with Se-yeast. Acta Veterinaria Brno, 76, 3-8.
Fisher A.D., Stewart, M., Duganzich, D.M., Tacon, J. and Matthews, L.R., 2005. The effects of stationary periods and external temperature and humidity on thermal stress conditions within sheep transport vehicles. New Zealand Veterinary Journal, 53, 6-9.
Garcia-Ispierto, I., Lopez-Gatius, F., Santolaria, P., Yaniz, J.L., Nogareda, C.N., Lopez-Bejar, M. and DeRenesis, F., 2006. Relationship between heat stress during the peri-implantation period and early fetal loss in dairy cattle. Theriogenology, 65, 799-807.
Heidarpour, M., Mohri, M., Borji, H. and Moghdass, E., 2012. Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis. Veterinary Parasitology, 187, 459-463.
Iranian Council of Animal Care, 1995. Guide to the care and use of experimental animals, vol. 1. Isfahan University of Technology, Isfahan.
Kumar, M., Garg, A.K., Dass, R.S., Chaturvedi, V.K., Mudgal, V. and Varshney, V.P., 2009. Selenium supplementation influences growth performance, antioxidant status and immune response in lambs. Animal Feed Science and Technology, 153, 77-87.
McDonald, P., Edwards, R.A., Greenhalgh, J.F.D., Morgan, A.C., Sinclair, L.A. and Wilkinson, R.G. 2010. Animal nutrition. 7th ed., Longman Scientific and Technical, New York, USA.
Mohri, M., Ehsani, A., Norouzian, M.A., Bami, M.H. and Seifi, H.A., 2011. Parenteral selenium and vitamin E supplementation to lambs: hematology, serum biochemistry, performance, and relationship with other trace elements. Biological Trace Element Research, 139, 308-316.
Moss, R.J., 1993. Rearing heifers in the subtropics: nutrient requirements and supplementation. Tropical Grasslands, 27, 238-249.
Mousaie, A., Valizadeh R., Naserian A.A., Heidarpour M. and Kazemi Mehrjerdi, H., 2014. Impacts of feeding selenium-methionine and chromium-methionine on performance, serum components, antioxidant status and physiological responses to transportation stress of Baluchi ewe lambs. Biological Trace Element Research, 162, 113-123.
Mousaie, A., Valizadeh, R. and Chamsaz, M., 2017. Selenium-methionine and chromium-methionine supplementation of sheep around parturition: impacts on dam and offspring performance. Archives of Animal Nutrition, 71, 134-149.
Paiva, F.A., Saran Netto, A., Correa, L.B., Silva, T.H., Guimaraes, I.C.S.B., Del Claro, G.R., Cunha, J.A. and Zanetti, M.A., 2019. Organic selenium supplementation increases muscle selenium content in growing lambs compared to inorganic source. Small Ruminant Research, 175, 57-64.
Placer, Z.A., Cushman, L. and Johnson, B., 1966. Estimation of product of lipid peroxidation (malonyldialdehyde) in biochemical system. Analytical Biochemistry, 16, 359-364.
Sadeghian, S., Kojouri, G.A. and Mohebbi, A., 2012. Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite. Biological Trace Element Research, 146, 302-308.
SAS Institute, 2003. SAS users’ guide. Version 9.1. SAS Institute Inc., Cary, NC.
Sevi, A., Annicchiarico, G., Albenzio, M., Taibi, L., Muscio, A. and Dell’Aquila, S., 2001. Effects of solar radiation and feeding time on behavior, immune response and production of lactating ewes under high ambient temperature. Journal of Dairy Science, 84, 629-640.
Shahid, A.B., Malhi, M., Soomro, S.A., Shah, M.G., Kalhoro, N.H., Kaka, A., Mal, R., Soomro, M.A., Samo, S.P. and Sanjrani, M.N., 2020. Influence of dietary selenium yeast supplementation on fermentation pattern, papillae morphology and antioxidant status in rumen of goat. Pakistan Journal of Zoology, 52, 565-571.
Shi, L., Xun, W., Yue, W., Zhang, C., Ren, Y., Shi, L., Wang, Q., Yang, R. and Lei, F., 2011. Effect of sodium selenite, Se-yeast and nano-elemental selenium on growth performance, Se concentration and antioxidant status in growing male goats. Small Ruminant Research, 96, 49-52.
Shi, L., Ren, Y., Zhang, C., Yue, W. and Lei, F., 2018. Effects of maternal dietary selenium (Se-enriched yeast) on growth performance, antioxidant status and haemato-biochemical parameters of their male kids in Taihang black goats. Animal Feed Science and Technology, 238, 57-65.
Silveira, R.M.F., Brito eSilva, B.E., de Vasconcelos, A.M., Facanha, D.A.E., Martins, T.P., Rogerio, M.C.P. and Ferreira, J., 2019. Does organic selenium supplement affect the thermoregulatory responses of dairy goats? Biological Rhythm Research. DOI: https://doi.org/10.1080/09291016.2019.1607988.
Valizadeh, R., 2014. Sheep and goat production. 3th ed., Ferdowsi University of Mashhad publication, Mashhad, Iran. (In Persian).
Wang, C., Liu, Q., Yang, W. Z., Dong, Q., Yang, X. M., He, D. C., Zhang, P., Dong, K. H. and Huang, Y.X., 2009. Effects of selenium yeast on rumen fermentation, lactation performance and feed digestibilities in lactating dairy cows. Livestock Science, 126, 239-244.
Wang, Z., Tan, Y., Cui, Z., Chang, S., Xiao, X., Yan, T., Wang, H. and Hou, F., 2019. Effect of different levels of selenium yeast on the antioxidant status, nutrient digestibility, selenium balances and nitrogen metabolism of Tibetan sheep in the Qinghai-Tibetan Plateau. Small Ruminant Research, 180, 63-69.
Xun, W., Shi, L., Yue, W., Zhang, C., Ren, Y., and Liu, Q., 2012. Effect of high-dose nano-selenium and selenium–yeast on feed digestibility, rumen fermentation, and purine derivatives in sheep. Biological Trace Element Research, 150, 130-136.
Yari, M., Nikkhah, A., Alikhani, M., Khorvash, M., Rahmani, H. and Ghorbani, G.R., 2010. Physiological calf responses to increased chromium supply in summer. Journal of Dairy Science, 93, 4111-4120.
The author would like to thank the Faculty of Agriculture, University of Jiroft, Iran, for providing the facilities and financial support of this study.
Animal handling and experimental procedures were performed according to the guidelines approved by Iranian Council of Animal Care (1995).
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Mousaie, A. Dietary supranutritional supplementation of selenium-enriched yeast improves feed efficiency and blood antioxidant status of growing lambs reared under warm environmental condition. Trop Anim Health Prod 53, 138 (2021). https://doi.org/10.1007/s11250-021-02588-4
- Blood metabolites
- Growth performance