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Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle

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Abstract

This study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10 mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2 h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24 h following the drug administration were significantly different from the control values (0 h) (P < 0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 ± 0.19 h), a large volume of distribution (6.30 ± 1.76 L/kg), and high total body clearance (5.31 ± 1.27 L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10 mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX.

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Acknowledgements

This study was presented in abstract form as a poster presentation in the 3rd International Convention of Pharmaceuticals and Pharmacies, Istanbul, Turkey, 26–29 April 2017.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42031, Konya, Turkey

    Kamil Uney & Bunyamin Tras

  2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Kastamonu, 37200, Kastamonu, Turkey

    Orhan Corum

  3. Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, 15030, Burdur, Turkey

    Ramazan Yildiz

  4. Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, 42031, Konya, Turkey

    Mehmet Maden

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  1. Kamil Uney
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  2. Bunyamin Tras
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  4. Ramazan Yildiz
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  5. Mehmet Maden
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Correspondence to Kamil Uney.

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The animal experiment was conducted in accordance with the procedure of Committee on Animal Use Ethics (Approval No. 2015/96).

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The authors declare that they have no conflict of interest.

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Uney, K., Tras, B., Corum, O. et al. Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle. Trop Anim Health Prod 51, 435–441 (2019). https://doi.org/10.1007/s11250-018-1710-8

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  • DOI: https://doi.org/10.1007/s11250-018-1710-8

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