The effects of PPR on the reproductive health of Black Bengal goats and the possible role played by oxidative stress

  • Pankaj Kumar
  • Amitava Dey
  • Abhay Kumar
  • Pradeep Kumar Ray
  • Poolangulam Chinnakkan Chandran
  • Rashmi Rekha Kumari
  • Manish Kumar
Regular Articles
Part of the following topical collections:
  1. The Gordon Scott Collection


Outbreaks of Peste des petits ruminants (PPR) viral disease in Black Bengal goats were investigated from the middle Indo-Gangetic Plains of India. Clinical profile of PPR-affected flocks was recorded from four different outbreak sites of the region. The PPR outbreak was diagnosed serologically using commercially available sandwich ELISA kit. Relatively, low mortality rate (mean 26.75%) for PPR outbreak was recorded due to the endemic status of the disease. To understand the role of oxidative stress in PPR virus pathogenesis, various oxidant and antioxidant parameters in goats infected with PPR were estimated and compared with the uninfected/healthy goats of the same flock. The measured high level of pro-oxidant malondialdehyde (MDA) obtained from lipid peroxidation along with lower levels of anti-oxidants viz. superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in PPR-affected Black Bengal goats suggests oxidative stress as one of the mechanism of pathogenesis of PPR virus. In addition, the correlation of oxidative stress due to PPR and the resulting reproductive disorders in the female goats were evaluated. The abortion in pregnant does observed during PPR outbreak was proportional to debility and oxidative stress manifested during PPR infection. The reproductive performance of recovered female goats in the period of 18 months of monitoring was significantly compromised in terms of kidding and twinning frequency. The mortality rate in kids born from PPR-recovered goats was significantly higher compared to those from health goats in the first 9 months post-recovery. From the present study, it may be concluded that together with the PPR virus, infection in goats and the resulting oxidative stress play a vital role for abortion and reduced post-reproductive performance in Black Bengal female goat.


Goat Black Bengal PPR Oxidative stress Reproduction 



The support provided by the Programme Coordinators of the Krishi Vigyan Kendras, Principal, Bihar Veterinary College, and the NAIP component-3 project field staff during survey, sampling and data recording is duly acknowledged. The authors are also thankful to the Station in Charge of IVRI Mukteshwar for providing ELISA kits.

Funding information

The authors acknowledge the support and cooperation of the Director of ICAR Research Complex for Eastern Region, Patna, for providing necessary funds and facilities for undertaking the institute project.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.ICAR Research Complex for Eastern RegionPatnaIndia
  2. 2.Division of Livestock and Fisheries ManagementICAR Research Complex for Eastern RegionPatnaIndia
  3. 3.Bihar Veterinary CollegePatnaIndia
  4. 4.Department of Biosciences and BioengineeringIIT GuwahatiGuwahatiIndia

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