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A ruthenium(II) complex with a methylated polypyridine ligand: synthesis, DNA binding, and antiproliferation activity

  • Yihui Jiang
  • Keke Chai
  • Tianzhi Han
  • Wei Zhang
  • Siyao Chen
  • Xiaoyu Xu
  • Linqing Nong
  • Yuanhua You
  • Jintao WangEmail author
Article
  • 42 Downloads

Abstract

A ruthenium polypyridine complex, [Ru(mptpy)(Mmptpy)Cl][PF6]2 (Ru1, mptpy = 4-(4-methylphenyl)-2,2′,6′,2″-mptpyridine, Mmptpy = 2-[4-(4-methylphenyl)-2,2′-bipyridin-6-yl]-1-methylpyridinum), was synthesised and characterised. The structure of the complex was determined by single-crystal X-ray crystallography. The ruthenium(II) core has an octahedral coordination environment. The interactions of the complex with DNA were analysed by UV–Vis and fluorescence spectroscopy, revealing a high binding affinity for double-stranded DNA. DNA photocleavage studies monitored by agarose gel electrophoresis showed that the complex cleaved DNA efficiently, whilst mechanistic studies showed that the complex produced reactive oxygen species including singlet oxygen, superoxide anions, and carbon-based radicals that cleave DNA. The complex also showed notable antiproliferation activity towards cancer cells in methyl thiazolyl tetrazolium assays.

Notes

Acknowledgements

We thank the Jiangxi Provincial Key Laboratory of Drug Design and Evaluation (20171BCD40015), Natural Science Foundation of Jiangxi Province (20181BAB213001), Graduate Students’ Science and Technology Innovation Project of Jiangxi Science & Technology Normal University (YC2017-X22), and College Students’ Science and Technology Innovation Project of Jiangxi Science & Technology Normal University (20181203021).

Supplementary material

11243_2019_336_MOESM1_ESM.docx (1.1 mb)
Supplementary material 1 (DOCX 1143 kb)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of PharmacyJiangxi Science & Technology Normal UniversityNanchangPeople’s Republic of China

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