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Transition Metal Chemistry

, Volume 43, Issue 4, pp 331–338 | Cite as

Kinetics and mechanism of interactions of some monofunctional Au(III) complexes with sulphur nucleophiles

  • Snežana Radisavljević
  • Ana Đeković Kesić
  • Snežana Jovanović
  • Biljana Petrović
Article
  • 84 Downloads

Abstract

Kinetics of the substitution reactions between monofunctional Au(III) complexes, [Au(dien)Cl]2+, [Au(bpma)Cl]2+ and [Au(terpy)Cl]2+ (dien = 3-azapentane-1,5-diamine, bpma = di-(2-picolyl) amine, terpy = 2,2′;6′,2″-terpyridine), and biologically relevant sulphur ligands, namely glutathione (GSH), l-methionine (l-Met) and l-cysteine (l-Cys), were studied in 0.1 M HCl (pH = 1.0). The reactions were followed under pseudo-first-order conditions as a function of ligand concentration and temperature using stopped-flow spectrophotometry. The [Au(terpy)Cl]2+ complex proved to be more reactive than the [Au(bpma)Cl]2+ and [Au(dien)Cl]2+ complexes. The reactivities of the nucleophiles follow the same order for all three complexes, viz. l-Met > GSH > l-Cys. Values of the activation parameters of the reactions support an associative substitution mechanism. In order to confirm that these monofunctional Au(III) complexes undergo a single substitution process in strongly acidic medium, the reaction between [Au(terpy)Cl]2+ and l-Met was studied by HPLC. At pH = 1.0, only one reaction product was detected.

Notes

Acknowledgements

The authors gratefully acknowledge financial support from the Ministry of Science and Technological Development of the Republic of Serbia (Project No. 172011).

Supplementary material

11243_2018_221_MOESM1_ESM.docx (63 kb)
Supplementary material 1 (DOCX 62 kb)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Snežana Radisavljević
    • 1
  • Ana Đeković Kesić
    • 2
  • Snežana Jovanović
    • 1
  • Biljana Petrović
    • 1
  1. 1.Faculty of ScienceUniversity of KragujevacKragujevacSerbia
  2. 2.Department of Chemical-Technological SciencesState University of Novi PazarNovi PazarSerbia

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