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Effect of a new inhibitor of factor Xa zifaxaban, on thrombosis in the inferior vena cava in rabbits

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Abstract

In recent years, oral factor Xa inhibitors have become a research focus as anticoagulant drugs. Zifaxaban is the first oral FXa inhibitor to enter clinical trials in China. The aim of this study was to determine the inhibitory effect of zifaxaban on thrombosisthrough a model ofinferior vena cava (IVC) thrombosis in rabbits. IVC thrombosis model was established by electrical injury and stenosis, and zifaxaban was administered (p.o.) for 5 consecutive days, then coagulation indicators and bleeding were observed. The results showed that zifaxaban had obvious inhibitory effects on FXa, and had a significant inhibitory effect on IVC thrombosis induced by electrical damage and stenosis. The effect of zifaxaban was similar to that of rivaroxaban, but the bleeding side-effects of zifaxaban were less severe than those of rivaroxaban. Zifaxaban could prolong the prothrombin time and activated partial thromboplastin time of plasma similar to that of other oral FXa inhibitors. Zifaxaban had a significant inhibitory effect on FXa, but it had no obvious effect on other coagulation factors, major anticoagulant factors or fibrinolytic indices. Our results suggest that zifaxaban had specific inhibitory effects on FXa and inhibited IVC thrombosis in rabbits with its hemorrhagic effect was less than that of rivaroxaban. Zifaxaban is ecpected to be developed as a new drug for the prevention of deep venous thrombosis, providing more medication options for patients with such disease, more research is required to support it in the future.

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Funding

This study was supported by the Special Program of Talents Development for Excellent Youth Scholars in Tianjin (TJTZJH-QNBJRC-2-7).

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Author notes

  1. Xiaomiao Qiu and Junjun Zhou contributed equally to the work.

Authors and Affiliations

  1. Tianjin Medical University School, Tianjin, 300070, People’s Republic of China

    Xiaomiao Qiu

  2. Department of Pharmacology, Dalian Medical University, Dalian, 116044, Liaoning, People’s Republic of China

    Junjun Zhou

  3. Tianjin Institute of Pharmaceutical Research New Drug Evaluation Co.Ltd, 308, Huiren Street, Binhai New Area, Tianjin, 300301, People’s Republic of China

    Weiting Wang, Zhuanyou Zhao, Lida Tang & Shuangyong Sun

Authors
  1. Xiaomiao Qiu
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  2. Junjun Zhou
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  3. Weiting Wang
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  4. Zhuanyou Zhao
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  5. Lida Tang
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  6. Shuangyong Sun
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Correspondence to Shuangyong Sun.

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The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Qiu, X., Zhou, J., Wang, W. et al. Effect of a new inhibitor of factor Xa zifaxaban, on thrombosis in the inferior vena cava in rabbits. J Thromb Thrombolysis 47, 80–86 (2019). https://doi.org/10.1007/s11239-018-1743-x

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  • DOI: https://doi.org/10.1007/s11239-018-1743-x

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