Is there a link among thrombophilia factors and preeclampsia?
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It is well established that pregnancy is associated with a hypercoagulability state that aims to prevent an exacerbated bleeding after placenta expulsion .
Preeclampsia (PE) is a challenging disease, characterized by hypertension and proteinuria. Preeclamptic women often present villous and vascular placental lesions, as consequence of ischemia after failed trophoblast invasion of maternal spiral arteries in early pregnancy. Subendothelial fibrin deposition in the decidual segments of spiral arteries and occlusive lesions in placental vasculature have been described in PE. It has been admitted that microthrombi formation in multiple maternal organs, including in the placenta, contribute to maternal clinical manifestations . It is known that PE pathological alterations begin as early as in the first trimester of pregnancy (before the onset of clinical symptoms), and the hypercoagulability might lead to multi-organ dysfunction contributing to disease development ....
The authors thank FAPEMIG and CNPq/Brazil financial support. LMD, MGC and KBG are grateful to CNPq Research Fellowship (PQ).
This study was funded by FAPEMIG/Brazil Award Number 00764-16.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in this study were in accordance with the institutional ethical standards and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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