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Platelet microRNA for predicting acute myocardial infarction

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Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide, while early diagnosis still represents an upmost priority. While platelet activation is critical for AMI pathogenesis, the role of platelet microRNAs (pmiRNAs) as biomarkers for AMI is unclear. Furthermore, correlations between the levels of pmiRNAs and indices of platelet activity are also unknown. Expression of platelet miR-1, miR-21, miR-126, miR-150 and miR-223 were prospectively assessed in 20 ST-segment elevation myocardial infarction (STEMI) patients, and 40 healthy volunteers. Platelet reactive units (PRU) were assessed with cartridge analyzer, and vasodilator-stimulated phosphoprotein (VASP) was measured by flow cytometry. There were no significant changes in pmiR-1 expression. Expressions of pmiR-21 and pmiR-126 were decreased, while pmiR-150 and pmiR-223 were increased in STEMI patients when compared to controls (all p < 0.01). However, only pmiR-126 exhibited correlation with plasma cardiac troponin I (r = − 0.556, p = 0.011) in STEMI. There was no correlation between pmiRNAs with PRU or VASP during admission, or at 48 h post-stenting. Among tested pmiRNAs, pmiR-126 may serve as a potential novel biomarker for STEMI, while pmiR-1, pmiR-21, pmiR-150, and pmiR-223 were not particularly useful. Moreover, since assessed pmiRNA expression did not correlate well with platelet activity indices their potential diagnostic utility is quite limited.

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Acknowledgements

This research was supported by the National Research Foundation of Korea (NRF) funded by the Korea government (MSIP) (2015R1C1A2A01052751). Part of this work was supported by the “Brain Pool” program funded by the Korea Ministry of Science and Technology to Dr. Serebruany.

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Author notes

  1. Shuhua Li and Long Zhe Guo have contributed equally to this work.

Authors and Affiliations

  1. Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, South Korea

    Shuhua Li & Jin-Yeong Han

  2. Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China

    Shuhua Li

  3. Department of Cardiology, Dong-A University College of Medicine, Busan, South Korea

    Long Zhe Guo & Moo Hyun Kim

  4. Department of Cardiology, The Fourth Hospital of Harbin Medical University, Harbin, China

    Long Zhe Guo

  5. Department of Neurology, Johns Hopkins University, Osler Medical Building, 7600 Osler Drive, Suite 307, Towson, Baltimore, MD, 21204, USA

    Victor Serebruany

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  1. Shuhua Li
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Correspondence to Jin-Yeong Han.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Li, S., Guo, L.Z., Kim, M.H. et al. Platelet microRNA for predicting acute myocardial infarction. J Thromb Thrombolysis 44, 556–564 (2017). https://doi.org/10.1007/s11239-017-1537-6

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  • DOI: https://doi.org/10.1007/s11239-017-1537-6

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