Journal of Thrombosis and Thrombolysis

, Volume 44, Issue 4, pp 556–564 | Cite as

Platelet microRNA for predicting acute myocardial infarction

  • Shuhua Li
  • Long Zhe Guo
  • Moo Hyun Kim
  • Jin-Yeong Han
  • Victor Serebruany
Article
  • 167 Downloads

Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide, while early diagnosis still represents an upmost priority. While platelet activation is critical for AMI pathogenesis, the role of platelet microRNAs (pmiRNAs) as biomarkers for AMI is unclear. Furthermore, correlations between the levels of pmiRNAs and indices of platelet activity are also unknown. Expression of platelet miR-1, miR-21, miR-126, miR-150 and miR-223 were prospectively assessed in 20 ST-segment elevation myocardial infarction (STEMI) patients, and 40 healthy volunteers. Platelet reactive units (PRU) were assessed with cartridge analyzer, and vasodilator-stimulated phosphoprotein (VASP) was measured by flow cytometry. There were no significant changes in pmiR-1 expression. Expressions of pmiR-21 and pmiR-126 were decreased, while pmiR-150 and pmiR-223 were increased in STEMI patients when compared to controls (all p < 0.01). However, only pmiR-126 exhibited correlation with plasma cardiac troponin I (r = − 0.556, p = 0.011) in STEMI. There was no correlation between pmiRNAs with PRU or VASP during admission, or at 48 h post-stenting. Among tested pmiRNAs, pmiR-126 may serve as a potential novel biomarker for STEMI, while pmiR-1, pmiR-21, pmiR-150, and pmiR-223 were not particularly useful. Moreover, since assessed pmiRNA expression did not correlate well with platelet activity indices their potential diagnostic utility is quite limited.

Keywords

Biomarkers Platelet microRNAs Acute myocardial infarction Platelet reactivity Antiplatelet therapy 

Notes

Acknowledgements

This research was supported by the National Research Foundation of Korea (NRF) funded by the Korea government (MSIP) (2015R1C1A2A01052751). Part of this work was supported by the “Brain Pool” program funded by the Korea Ministry of Science and Technology to Dr. Serebruany.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Shuhua Li
    • 1
    • 2
  • Long Zhe Guo
    • 3
    • 4
  • Moo Hyun Kim
    • 3
  • Jin-Yeong Han
    • 1
  • Victor Serebruany
    • 5
  1. 1.Department of Laboratory MedicineDong-A University College of MedicineBusanSouth Korea
  2. 2.Department of NephrologyHeilongjiang Academy of Traditional Chinese MedicineHarbinChina
  3. 3.Department of CardiologyDong-A University College of MedicineBusanSouth Korea
  4. 4.Department of CardiologyThe Fourth Hospital of Harbin Medical UniversityHarbinChina
  5. 5.Department of NeurologyJohns Hopkins UniversityBaltimoreUSA

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