Two small molecular propellers and their rotational potential energy surfaces
Molecular propellers based upon the twisting of a disulfide bond are analyzed here as the locomotion source for fullerene nanoparticles. The HC(CCHSSHCC)3CH and related HC(CCHSSNC)3CH bicyclic compounds are optimized and linked to pyracyclene functioning as a model fullerene surface. It is shown that steric hinderance from the hydrogen atoms on both the bottom of the propeller blade and the linker to the fullerene surface can have significant effects on the rotational potential energy surface. Replacing the bottom CH groups on the molecular propeller with nitrogen atoms not only reduces these barriers significantly, but this action creates a strongly dipolar molecule in HC(CCHSSNC)3CH. Such a system would be responsive to and controllable with an external, rotating, magnetic or electric field. Endohedral fullerenes have known applications for targeted delivery, especially in nanomedicine. Providing further control with molecular propellers could enhance the feasibility and use of these technologies.
KeywordsNanotechnology Molecular propellers Disulfide bonds Quantum chemistry Drug delivery
Georgia Southern University is thanked for the start-up funds and computer hardware/software necessary to perform this research. Additionally, the WebMO graphical user interface  was utilized in the production of the molecules given in the figures.
- 3.Terrones M, Hsu WK, Kroto HW, Walton DRM (1999). In: Hirsch A (ed) Fullerenes and related structures. Springer, Berlin, pp 189–234Google Scholar
- 12.Colledge JJ, Warlow B (2010) Ships of the Royal Navy: a complete record of all fighting ships of the Royal Navy from the 15th century to the present., 4th edn. PA, Casemate, HavertownGoogle Scholar
- 19.Rubin Y (1999). In: Hirsch A (ed) Fullerenes and related structures. Springer, Berlin, pp 67–91Google Scholar
- 25.Fortenberry RC (2016) New J Chem 40:8149Google Scholar
- 27.Sherrill CD (2011) Rev Comput Chem 26:1Google Scholar
- 29.Turney JM, Simmonett AC, Parrish RM, Hohenstein EG, Evangelista FA, Fermann JT, Mintz BJ, Burns LA, Wilke JJ, Abrams ML, Russ NJ, Leininger ML, Janssen CL, Seidl ET, Allen WD, Schaefer III HF, King RA, Valeev EF, Sherrill CD, Crawford TD (2012) Wiley Interdiscip Rev: Comput Mol Sci 2(4): 556Google Scholar
- 30.Schmidt JR, Polik WF (2013) WebMO Enterprise, version 13.0; WebMO LLC: Holland, MI, USA. http://www.webmo.net
- 31.Lomas JS, Adenier A (2002) J Chem Soc, Perkin Trans 2:1051Google Scholar
- 32.Fortenberry RC, Francisco JS (2017) Astrophys J 835:243Google Scholar