Table 6 The 25 pairs of drug-disease relations with contradiction

From: Towards medical knowmetrics: representing and computing medical knowledge using semantic predications as the knowledge unit and the uncertainty as the knowledge context

  Subject Predicate (# claims) Object Category
Topic—1 Benzo(A)Pyrene CAUSES (3) Carcinogenesis Category—1
NEG_CAUSES (1)
AUGMENTS (1)
Topic—2 Beta Carotene NEG_PREVENTS (3) PREVENTS (1) Malignant neoplasm of lung Category—2
PREDISPOSES (3) AUGMENTS (2)
Topic—3 Carboplatin PREVENTS (1) Thrombocytopenia Category—1, 7
TREATS (1)
CAUSES (1)
Topic—4 Cetuximab TREATS (9) Non-Small Cell Lung Carcinoma Category—3
NEG_TREATS (1)
Topic—5 Cisplatin TREATS (1) Non-Squamous Non-Small Cell Lung Carcinoma Category—3
NEG_TREATS (1)
Topic—6 Cisplatin TREATS (5) Small cell carcinoma of lung Category—4
NEG_TREATS (1)
Topic—7* Cotinine PREDISPOSES (1) Malignant neoplasm of lung
NEG_PREDISPOSES (1)
Topic—8 Dacomitinib TREATS (1) Non-Small Cell Lung Carcinoma Category—1
NEG_TREATS (1)
Topic—9 Docetaxel TREATS (1) Febrile Neutropenia Category—1
CAUSES (1)
Topic—10* Epidermal Growth Factor Receptor DISRUPTS (1) Tumor growth
CAUSES (1)
Topic—11 Erlotinib NEG_AUGMENTS (1) Lung Diseases, Interstitial Category—5
PREDISPOSES (1)
Topic—12 Etoposide TREATS (4) Small cell carcinoma of lung Category—4
NEG_TREATS (1)
Topic—13 Irinotecan TREATS (3) Small cell carcinoma of lung Category—4
NEG_TREATS (1)
Topic—14 Isotretinoin TREATS (1) Malignant neoplasm of lung Category—6
NEG_PREVENTS (2)
Topic—15* Matrix Metalloproteinase 2 PREVENTS (1) Malignant neoplasm of lung
PREDISPOSES (1)
Topic—16 Paclitaxel TREATS (2) extensive stage small cell lung cancer Category—1
NEG_TREATS (1)
Topic—17 Particle TREATS (2) stage I non-small cell lung cancer Category—4
NEG_TREATS (1)
Topic—18 Pemetrexed TREATS (4) Non-Small Cell Lung Carcinoma Category—1
NEG_TREATS (1)
Topic—19* Rasagiline TREATS (2) Malignant neoplasm of lung
CAUSES (1)
Topic—20 Selenium PREVENTS (1) Malignant neoplasm of prostate Category—2
NEG_PREVENTS (1)
Topic—21 Tamoxifen TREATS (1) Malignant Neoplasms Category—1
PREDISPOSES (1)
Topic—22 Vitamin E PREVENTS (1) Malignant neoplasm of prostate Category—1
NEG_PREVENTS (1)
Topic—23 Anthracyclines TREATS (3) Carcinoma breast stage IV Category—1
NEG_TREATS (1)
Topic—24 Capecitabine TREATS (2) Carcinoma breast stage IV Category—1
NEG_TREATS (1)
Topic—25 Taxane TREATS (2) Carcinoma breast stage IV Category—1
NEG_TREATS (1)
  1. *Not in the scope of the present study