Advertisement

Scientometrics

, Volume 80, Issue 1, pp 39–58 | Cite as

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

  • Ling-Li Li
  • Guohua Ding
  • Nan Feng
  • Ming-Huang Wang
  • Yuh-Shan Ho
Article

Abstract

In this study, we aim to evaluate the global scientific production of stem cell research for the past 16 years and provide insights into the characteristics of the stem cell research activities and identify patterns, tendencies, or regularities that may exist in the papers. Data are based on the online version of SCI, Web of Science from 1991 to 2006. Articles referring to stem cell were assessed by many aspects including exponential fitting the trend of publication outputs during 1991–2006, distribution of source title, author keyword, and keyword plus analysis. Based on the exponential fitting the yearly publicans of the last decade, it can also be calculated that, in 2,011, the number of scientific papers on the topic of stem-cell will be twice of the number of publications in 2006. Synthetically analyzing three kinds of keywords, it can be concluded that application of stem cell transplantation technology to human disease therapy, especially research related on “embryonic stem cell” and “mesenchymal stem cell” is the orientation of all the stem cell research in the 21st century. This new bibliometric method can help relevant researchers realize the panorama of global stem cell research, and establish the further research direction.

Keywords

Stem Cell Mesenchymal Stem Cell Embryonic Stem Cell Hematopoietic Stem Cell Science Citation Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrous, D. N., Koehl, M., Le Moal, M. (2005), Adult neurogenesis: From precursors to network and physiology. Physiological Reviews, 85(2): 523–569.CrossRefGoogle Scholar
  2. Arrue, J. L., Lopez, M. V. (1991), Conservation tillage research trends and priorities. Suelo Y Planta, 1(4): 555–564.Google Scholar
  3. Arunachalam, S., Jinandra, D. M. (2000), Mapping international collaboration in science in Asia through coauthorship analysis. Current Science, 79(5): 621–628.Google Scholar
  4. Attal, M., Harousseau, J. L., Stoppa, A. M., Sotto, J. J., Fuzibet, J. G., Rossi, J. F., Casassus, P., Maisonneuve, H., Facon, T., Ifrah, N., Payen, C., Bataille, R. (1996), A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. New England Journal of Medicine, 335(2): 91–97.CrossRefGoogle Scholar
  5. Bayer, A. E., Folger, J. (1966), Some correlates of a citation measure of productivity in science. Sociology of Education, 39(4): 381–390.CrossRefGoogle Scholar
  6. Bensinger, W. I., Martin, P. J., Storer, B., Clift, R., Forman, S. J., Negrin, R., Kashyap, A., Flowers, M. E. D., Lilleby, K., Chauncey, T. R., Storb, R., Appelbaum, F. R., Rowley, S., Heimfeld, S., Blume, K. (2001), Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. New England Journal of Medicine, 344(3): 175–181.CrossRefGoogle Scholar
  7. Braun, T., Glänzel, W., Grupp, H. (1995), The scientometric weight of 50 nations in 27 science areas, 1989–1993. Part I. All fields combined, mathematics, engineering, chemistry and physics. Scientometrics, 33(3): 263–293.CrossRefGoogle Scholar
  8. Braun, T., Schubert, A. P., Kostoff, R. N. (2000), Growth and trends of fullerene research as reflected in its journal literature. Chemical Reviews, 100(1): 23–38.CrossRefGoogle Scholar
  9. Bruder, S. P., Kurth, A. A., Shea, M., Hayes, W. C., Jaiswal, N., Kadiyala, S. (1998), Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. Journal of Orthopaedic Research, 16(2): 155–162.CrossRefGoogle Scholar
  10. Burd, A., Ahmed, K., Lam, S., Ayyappan, T., Huang, L. (2007), Stem cell strategies in burns care. Burns, 33(3): 282–291.CrossRefGoogle Scholar
  11. Cao, Q. L., Benton, R. L., Whittemore, S. R. (2002), Stem cell repair of central nervous system injury. Journal of Neuroscience Research, 68(5): 501–510.CrossRefGoogle Scholar
  12. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., Nagy, A. (1996), Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 380(6573): 435–439.CrossRefGoogle Scholar
  13. Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., Smith, A. (2003), Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell, 113(5): 643–655.CrossRefGoogle Scholar
  14. Cherveni, P. A., Boggs, D. R. (1969), Kinetic model of hematopoietic stem cell repopulation and differentiation. Journal of Clinical Investigation, 48(6): A15–A20.Google Scholar
  15. Chiu, W. T., Ho, Y. S. (2007), Bibliometric analysis of tsunami research. Scientometrics, 73(1): 3–17.CrossRefGoogle Scholar
  16. Chuang, K. Y., Huang, Y. L., Ho, Y. S. (2007), A bibliometric and citation analysis of stroke-related research in Taiwan. Scientometrics, 72(2): 201–212.CrossRefGoogle Scholar
  17. Cole, S. (1989), Citation and the evaluation of individual scientiste. Trends in Biochemical Sciences, 14(1): 9–13.CrossRefGoogle Scholar
  18. Colman, A. M., Dhillon, D., Coulthard, B. (1995), A bibliometric evaluation of the research performance of British university politics departments: Publications in leading journals. Scientometrics, 32(1): 49–66.CrossRefGoogle Scholar
  19. Cross, J. C., Baczyk, D., Dobric, N., Hemberger, M., Hughes, M., Simmons, D. G., Yamamoto, H., Kingdom, J. C. P. (2003), Genes, development and evolution of the placenta. Placenta, 24(2–3): 123–130.CrossRefGoogle Scholar
  20. Dennis N. (2000), Stem cells: Report would open up research in Japan. Science, 287(5455): 949–951.Google Scholar
  21. Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T., Eggan, K. (2007), Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature Neuroscience, 10(5): 608–614.CrossRefGoogle Scholar
  22. Fenstermacher, D. (2007), Stem cell research — The promise and current progress. Proceedings of the IEEE, 95(2): 323–324.CrossRefGoogle Scholar
  23. Frank, E. Y. (2000), A time for restraint. Science, 287(5457): 1424.CrossRefGoogle Scholar
  24. Garfield, E. (1990), Keywords plus-ISIS breakthrough retrieval method. 1. Expanding your searching power on current-contents on diskette. Current Contents, 32: 5–9.Google Scholar
  25. Gretchen V. (1999), Breakthrough of the year: Capturing the promise of youth. Science, 286(5488): 2238–2239.Google Scholar
  26. Guenin, L. M. (2005), A proposed stem cell research policy. Stem Cells, 23(8): 1023–1027.CrossRefGoogle Scholar
  27. Gupta, S., Verfaillie, C., Chmielewski, D., Kim, Y., Rosenberg, M. E. (2002), A role for extrarenal cells in the regeneration following acute renal failure. Kidney International, 62(4): 1285–1290.CrossRefGoogle Scholar
  28. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Tunio, G.M., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., Kitamura, Y. (1998), Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279(5350): 577–580.CrossRefGoogle Scholar
  29. Ho, Y. S., Chiu, C. H., Tseng, T. M., Chiu, W. T. (2003), Assessing stem cell research productivity. Scientometrics, 57(3): 369–376.CrossRefGoogle Scholar
  30. Ho, Y. S. (2007), Bibliometric analysis of adsorption technology in environmental science. Journal of Environmental Protection Science, 1(1): 1–11.Google Scholar
  31. Hynes, M., Rosenthal, A. (2000), Embryonic stern cells go dopaminergic. Neuron, 28(1): 11–14.CrossRefGoogle Scholar
  32. Jiang, Y. H., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J. B., Aldrich, S., Lisberg, A., Low, W. C., Largaespada, D. A., Verfaillie, C. M. (2002), Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 418(6893): 41–49.CrossRefGoogle Scholar
  33. Keiser, J., Utzinger, J. (2005), Trends in the core literature on tropical medicine: A bibliometric analysis from 1952–2002. Scientometrics, 62(3): 351–365.CrossRefGoogle Scholar
  34. Krause, D. S., Theise, N. D., Collector, M. I., Henegariu, O., Hwang, S., Gardner, R., Neutzel, S., Sharkis, S. J. (2001), Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell, 105(3): 369–377.CrossRefGoogle Scholar
  35. Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., Grompe, M. (2000), Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Medicine, 6(11): 1229–1234.CrossRefGoogle Scholar
  36. Li, W. J., Laurencin, C. T., Caterson, E. J., Tuan, R. S., Ko, F. K. (2002), Electrospun nanofibrous structure: A novel scaffold for tissue engineering. Journal of Biomedical Materials Research, 60(4): 613–621.CrossRefGoogle Scholar
  37. Liechty, K. W., Mackenzie, T. C., Shaaban, A. F., Radu, A., Moseley, A. B., Deans, R., Marshak, D. R., Flake, A. W. (2000), Human mesenchymal stem cells engraft and demonstrate sitespecific differentiation after in utero transplantation in sheep. Nature Medicine, 6(11): 1282–1286.CrossRefGoogle Scholar
  38. Marr, K. A., Carter, R. A., Crippa, F., Wald, A., Corey, L. (2002), Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clinical Infectious Diseases, 34(7): 909–917.CrossRefGoogle Scholar
  39. Martinezserrano, A., Bjorklund, A. (1996), Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. Journal of Neuroscience, 16(15): 4604–4616.Google Scholar
  40. Mela, G. S., Cimmino, M. A., Ugolini, D. (1999), Impact assessment of oncology research in the European Union. European Journal of Cancer, 35(8): 1182–1186.CrossRefGoogle Scholar
  41. Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B. S., Pickel, J., Mckay, R., Nadal-Ginard, B., Bodine, D. M., Leri, A., Anversa, P. (2001), Bone marrow cells regenerate infarcted myocardium. Nature, 410(6829): 701–705.CrossRefGoogle Scholar
  42. Palmer, A. L., Sese, A., Montano, J. J. (2005), Tourism and statistics — Bibliometric study 1998–2002. Annals of Tourism Research, 32(1): 167–178.CrossRefGoogle Scholar
  43. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., Marshak, D. R. (1999), Multilineage potential of adult human mesenchymal stem cells. Science, 284(5411): 143–147.CrossRefGoogle Scholar
  44. Qin, J. (2000), Semantic similarities between a keyword database and a controlled vocabulary database: An investigation in the antibiotic resistance literature. Journal of the American Society for Information Science, 51(2): 166–180.CrossRefGoogle Scholar
  45. Rodríguez, K., Moreiro, J. A. (1996), The growth and development of research in the field of ecology as measured by dissertation title analysis. Scientometrics, 35(1): 59–70.CrossRefGoogle Scholar
  46. Rossi, F., Cattaneo, E. (2002), Opinion — Neural stem cell therapy for neurological diseases: dreams and reality. Nature Reviews Neuroscience, 3(5): 401–409.CrossRefGoogle Scholar
  47. Schutz, H., Six, B. (1994), More than 7000 pages of social-psychology: A journal in retrospect. Zeitschrift fur Sozialpsychologie, 25(1): 5–17.Google Scholar
  48. Slavin, S., Nagler, A., Naparstek, E., Kapelushnik, Y., Aker, M., Cividalli G., Varadi, G., Kirschbaum, M., Ackerstein, A., Samuel, S., Amar, A., Brautbar, C., Ben-Tal, O., Eldor, A., Or, R. (1998), Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood, 91(3): 756–763.Google Scholar
  49. Tang, R., Thelwall, M. (2003), US academic departmental Web-site interlinking in the United States disciplinary differences. Library & Information Science Research, 25(4): 437–458.CrossRefGoogle Scholar
  50. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., Jones, J. M. (1998), Embryonic stem cell lines derived from human blastocysts. Science, 282(5391): 1145–1147.CrossRefGoogle Scholar
  51. Trajtenberg, M. (2001), Innovation in Israel 1968–1997: A comparative analysis using patent data. Research Policy, 30(3): 363–389.CrossRefGoogle Scholar
  52. Ugolini, D., Parodi, S., Santi, L. (1997), Analysis of publication quality in a cancer research institute. Scientometrics, 38(2): 265–274.CrossRefGoogle Scholar
  53. Wang, X. L., Ge, S. D., Mcnamara, G., Hao, C. L., Crooks, G. M., Nolta, J. A. (2003), Albuminexpressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood, 101(10): 4201–4208.CrossRefGoogle Scholar
  54. Ying, Q. L., Nichols, J., Evans, E. P., Smith, A. G. (2002), Changing potency by spontaneous fusion. Nature, 416(6880): 545–548.CrossRefGoogle Scholar
  55. Zitt, M., Bassecoulard, E. (1994), Development of a method for detection and trend analysis of research fronts built by lexical or cocitation analysis. Scientometrics, 30(1): 333–351.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • Ling-Li Li
    • 1
  • Guohua Ding
    • 2
  • Nan Feng
    • 3
  • Ming-Huang Wang
    • 3
  • Yuh-Shan Ho
    • 3
    • 4
  1. 1.Department of EmergencyPeople’s Hospital of Wuhan UniversityWuhanP. R. China
  2. 2.Department of NephrologyPeople’s Hospital of Wuhan UniversityWuhanP. R. China
  3. 3.Department of Environmental Sciences, College of Environmental Science and EngineeringPeking UniversityBeijingP. R. China
  4. 4.Trend Research CentreAsia UniversityTaichungTaiwan

Personalised recommendations