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Russian Journal of Organic Chemistry

, Volume 41, Issue 7, pp 967–973 | Cite as

Prostanoids: XC. Extension to the Synthesis of Enprostil of the o-Nitrophenylsulfonylhydrazine Method for Transformation of 2-Propynyl Alcohols into Allenes

  • N. S. Vostrikov
  • V. Z. Vasikov
  • M. S. Miftakhov
Article

Abstract

A potential precursor of enprostil, (±)-9-acetoxy-11,15-di-O-(tert-butyldimethylsilyl)-2-decarboxy-6-hydroxy-16-phenoxy-2-triphenylmethyloxymethyl-4,4,5,5-tetradehydro-17,18,19,20-tetranorprostaglandin F1α, was synthesized. This compound remained unchanged under the conditions for generation of allenes from 2-propynyl alcohols by the action of the system diisopropyl azodicarboxylate-triphenylphosphine-o-nitrophenylsulfonylhydrazine.

Keywords

Alcohol Organic Chemistry Diisopropyl Potential Precursor Enprostil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • N. S. Vostrikov
    • 1
  • V. Z. Vasikov
    • 1
  • M. S. Miftakhov
    • 1
  1. 1.Institute of Organic Chemistry, Ufa Research CenterRussian Academy of SciencesUfa, BashkortostanRussia

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