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Russian Journal of Organic Chemistry

, Volume 41, Issue 6, pp 875–883 | Cite as

Synthesis and Structure of 5-Indolyl-6-thienyl-1,2,4-triazines

  • M. M. Krayushkin
  • V. N. Yarovenko
  • I. P. Sedishev
  • I. V. Zavarzin
  • L. G. Vorontsova
  • Z. A. Starikova
Article

Abstract

Acylation of indole and 2,5-dimethylthiophene with 2-(3-indolyl)-2-oxoacetyl chloride afforded the corresponding diketones. 1-(2,5-Dimethyl-3-thienyl)-2-(3-indolyl)ethanedione reacted with thiosemicarbazide under atmosperic and elevated pressure to give 6-(2,5-dimethyl-3-thienyl)-5-(3-indolyl)-2,3-dihydro-1,2,4-triazine-3-thione whose structure was studied in detail by the X-ray diffraction method. Reactions of 6-(2,5-dimethyl-3-thienyl)-5-(3-indolyl)-2,3-dihydro-1,2,4-triazine-3-thione with amines and hydrazine resulted in formation of fused triazolo- and tetrazolotriazines.

Keywords

Ethanedione Chloride Organic Chemistry Indole Hydrazine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • M. M. Krayushkin
    • 1
  • V. N. Yarovenko
    • 1
  • I. P. Sedishev
    • 1
  • I. V. Zavarzin
    • 1
  • L. G. Vorontsova
    • 1
  • Z. A. Starikova
    • 2
  1. 1.Zelinskii Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia
  2. 2.Nesmeyanov Institute of Organometallic CompoundsRussian Academy of SciencesMoscowRussia

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