Advertisement

Russian Journal of Organic Chemistry

, Volume 41, Issue 4, pp 607–609 | Cite as

Desulfurization of 2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-ones with Oxiranes and 2-Haloacetonitriles

  • I. A. Novakov
  • B. S. Orlinson
  • M. B. Navrotskii
Article

Abstract

A procedure was developed for the synthesis of tetrahydropyrimidine-2,4-diones by desulfurization of 2-thioxo-1,2,3,4-tetrahydropyrimidin-4-ones with oxiranes or 2-haloacetonitriles in polar solvents in the presence of a base.

Keywords

Organic Chemistry Diones Desulfurization Polar Solvent Oxiranes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Mai, A., Artico, M., Sbardella, G., Massa, S., Novellino, E., Greso, G., Loi, A.G., Tramontano, E., Marongiu, M.E., and La Colla, R., J. Med. Chem., 1999, vol. 42, p. 619.CrossRefPubMedGoogle Scholar
  2. 2.
    Pedersen, O.S., Petersen, L., Brandt, M., Nielsen, C., and Pedersen, E.B., Monatsh. Chem., 1999, vol. 130, p. 1499.Google Scholar
  3. 3.
    Danel, K., Larsen, E., Pedersen, E.B., Vestergaard, B.F., and Nielsen C., J. Med. Chem., 1996, vol. 39, p. 2427.PubMedGoogle Scholar
  4. 4.
    Al’fonsov, V.A., Belen’kii, L.I., Vlasova, N.N., Voronkov, M.G., Gereshenovich, A.I., Deryagina, A.P., Drozd, V.N., Dudinov, A.A., Karaulova, V.N., Knutov, V.I., Komarova, E.N., Levchenko, E.S., Mazaev, V.N., Markovskii, L.N., Nedel’kin, V.I., Nizamov, I.S., Prilezhaeva, E.N., Salov, B.V., Stoyanovich, F.M., Uzhdavini, E.R., Usov, V.A., Kharchenko, V.G., Chalaya, S.N., and Shermolovich, Yu.G., Poluchenie i svoistva organicheskikh soedinenii sery (Synthesis and Properties of Organic Sulfur Compounds), Moscow: Khimiya, 1998, p. 560.Google Scholar
  5. 5.
    Weygand-Hilgetag Organisch-chemische Experimentierkunst, Hilgetag, G. and Martini, A., Eds., Leipzig: Johann Ambrosius Barth, 1964, 3rd ed. Translated under the title Metody eksperimenta v organicheskoi khimii, Moscow: Khimiya, 1968, p. 944.Google Scholar
  6. 6.
    Danel, K., Nielsen, C., and Pedersen E.B., Acta Chem. Scand., 1997, vol. 51, p. 426.PubMedGoogle Scholar
  7. 7.
    Danel, K., Pedersen, E.B., and Nielsen, C., J. Med. Chem., 1998, vol. 41, p. 191.PubMedGoogle Scholar
  8. 8.
    The Merck Index, N.J.: Merck & Co., 2001, 13th ed.Google Scholar
  9. 9.
    Johnson, T.B. and Ambelang J.C., J. Am. Chem. Soc., 1938, vol. 60, p. 2941.Google Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • I. A. Novakov
    • 1
  • B. S. Orlinson
    • 1
  • M. B. Navrotskii
    • 1
  1. 1.Volgograd State Technical UniversityVolgogradRussia

Personalised recommendations