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Russian Journal of Genetics

, Volume 41, Issue 12, pp 1419–1424 | Cite as

In Silico Identification and Characterization of Meiotic DNA: AluJb Possibly Participates in the Attachment of Chromatin Loops to Synaptonemal Complex

  • S. Ya. Dadashev
  • T. M. Grishaeva
  • Yu. F. Bogdanov
Mathematical Models and Methods

Abstract

Earlier, using bioinformatic methods, we reported the identification of repeated DNA sequences (RSs), presumably responsible for the attachment of chromatin loops to the lateral elements of synaptonemal complex in meiotic chromosomes. In the present study, consensus sequences for this class of RS were identified. It was demonstrated that at least part of these sequences belonged to the AluJb subfamily of Alu sequences. The Alu copies distribution along the major human histocompatibility complex (MHC) and their spatial separation from the sites of meiotic recombination was examined. It was demonstrated that simple sequences, like (GT/CA) n , were flanking meiotic recombination sites. A model of the RS organization in meiotic chromosome, most efficiently linking experimental data on the meiotic recombination in MHC and the in silico data on the RS localization (the coefficient of multiple correlation, r = 0.92) is suggested.

Keywords

Experimental Data Consensus Sequence Spatial Separation Synaptonemal Complex Meiotic Recombination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • S. Ya. Dadashev
    • 1
  • T. M. Grishaeva
    • 1
  • Yu. F. Bogdanov
    • 1
  1. 1.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia

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