Russian Journal of Genetics

, Volume 41, Issue 10, pp 1151–1156 | Cite as

Cytogenetic Analysis of Spermatozoa in a Patient with Chromosome Constitution 45,X/46,X,r(Y) by Intracytoplasmic Injection into Mouse Oocytes

  • I. D. Fedorova
  • T. V. Kuznetsova
  • J. Van der Elst
  • M. Dhont
  • V. S. Baranov
Human Genetics


The chromosome set of human spermatozoa was studied by intracytoplasmic injection into mouse oocytes. A total of 85 metaphase plates of male pronuclei of a patient with chromosome constitution 45,X/46,X,r(Y) and 108 metaphase plates of patients with normal sperm parameters (control group) were examined. The ratio between X- and Y-bearing chromosomes in the 45,X/46,X,r(Y) patient and in the control group did not differ from 1 : 1. A significant increase in the rates of diploidy, hypoploidy, hyperploidy of sex chromosomes, and chromosome structure rearrangements in spermatozoa of the patient in comparison with spermatozoa in the control group was recorded.


Cytogenetic Analysis Structure Rearrangement Chromosome Structure Human Spermatozoon Metaphase Plate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • I. D. Fedorova
    • 1
    • 2
  • T. V. Kuznetsova
    • 1
  • J. Van der Elst
    • 3
  • M. Dhont
    • 3
  • V. S. Baranov
    • 1
  1. 1.Ott Institute of Obstetrics and GynecologyRussian Academy of Medical SciencesSt. PetersburgRussia
  2. 2.Department of Genetics and BreedingSt. Petersburg State UniversitySt. PetersburgRussia
  3. 3.Infertility Center, Department of Gynecology and ObstetricsUniversity Hospital of GhentGhentBelgium

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