Russian Journal of General Chemistry

, Volume 75, Issue 1, pp 134–146 | Cite as

Azines and Azoles: CXXII. New Regioselective Synthesis of 1-Substituted 6-Alkyluracils

  • V. N. Yuskovets
  • A. V. Moskvin
  • L. E. Mikhailov
  • B. A. Ivin


Readily available 5-acyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-diones with primary alkyl- and arylamines in mild conditions (boiling in propan-2-ol) to give Schiff bases. In more rigid conditions (boiling in DMF), the reaction is accompanied by COS liberation and provides 1-substituted 6-alkyluracils. This previously unknown reaction possesses a considerable synthetic potential and can be considered as a new, general, and regioselective synthetic approach to 1-substituted 6-alkyluracils.


Diones Schiff Base Schiff Mild Condition Azole 


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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • V. N. Yuskovets
    • 1
  • A. V. Moskvin
    • 1
  • L. E. Mikhailov
    • 1
  • B. A. Ivin
    • 1
  1. 1.St. Petersburg State Chemical Pharmaceutical AcademySt. PetersburgRussia

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