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Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments

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Abstract

A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.

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Authors and Affiliations

  1. Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomaiskaya, 167000, Syktyvkar, Russian Federation

    I. A. Dvornikova, E. V. Buravlev, I. V. Fedorova, I. Yu. Chukicheva & A. V. Kutchin

  2. Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko

Authors
  1. I. A. Dvornikova
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  2. E. V. Buravlev
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  3. I. V. Fedorova
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  4. O. G. Shevchenko
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  5. I. Yu. Chukicheva
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  6. A. V. Kutchin
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Corresponding author

Correspondence to I. A. Dvornikova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1000–1005, May, 2019.

The work was performed within the State Assignment of the Ministry of Science and Higher Education of the Russian Federation (State Assignment Nos AAAA-A18-118012490385-8 and AAAA-A18-118011120004-5).

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Dvornikova, I.A., Buravlev, E.V., Fedorova, I.V. et al. Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments. Russ Chem Bull 68, 1000–1005 (2019). https://doi.org/10.1007/s11172-019-2510-7

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  • DOI: https://doi.org/10.1007/s11172-019-2510-7

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