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2-Hydroxy-3-isobornyl-5-methylbenzaldehyde derivatives: synthesis and antioxidant activity in vitro

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Abstract

A series of N- and O-containing derivatives based on 2-hydroxy-3-isobornyl-5-methylbenzaldehyde was synthesized. A comparative evaluation of their radical scavenging activity tested with diphenylpicrylhydrazyl, antioxidant activity estimated on a substrate containing animal lipids, Fe2+-chelating ability using the FerroZine™ Iron Reagent, cytotoxicity, and also antioxidant and membrane-protective properties towards mammalian red blood cells was performed. The listed properties of the synthesized derivatives are essentially determined by the structure of the substituent introduced at the ortho-position. Compounds exhibiting a high activity in both cellular and non-cellular models were revealed.

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomayskaya, 167000, Syktyvkar, Russian Federation

    E. V. Buravlev

  2. Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko

Authors
  1. E. V. Buravlev
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  2. O. G. Shevchenko
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Correspondence to E. V. Buravlev.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0079–0085, January, 2019.

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Buravlev, E.V., Shevchenko, O.G. 2-Hydroxy-3-isobornyl-5-methylbenzaldehyde derivatives: synthesis and antioxidant activity in vitro. Russ Chem Bull 68, 79–85 (2019). https://doi.org/10.1007/s11172-019-2419-1

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  • DOI: https://doi.org/10.1007/s11172-019-2419-1

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