Acyl derivatives of ivermectin 5-oxime with antifungal activity

Abstract

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.

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Correspondence to I. V. Zavarzin.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0438–0444, February, 2019.

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Chernoburova, E.I., Shchetinina, M.A., Dzhafarov, M.K. et al. Acyl derivatives of ivermectin 5-oxime with antifungal activity. Russ Chem Bull 68, 438–444 (2019). https://doi.org/10.1007/s11172-019-2405-7

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Key words

  • acyl derivatives of ivermectin 5-oxime
  • ivermectin
  • carboxylic acids
  • acyl chlorides
  • antifungal activity