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Methyl esters of 2-aminotetrahydrobenzothiophene-3-carboxylic acids decorated with trifluoromethyl-containing heterocycles

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Abstract

Methyl 2-aminothiophene-3-carboxylates were modified with trifluoromethyl-containing five-membered heterocycles by cyclocondensation of methyl trifluoropyruvate N-thiophen-2-ylimines with 1,3-N,N-binucleophiles (2-aminothiazoline and benzamidines) to obtain the corresponding 5-oxo-6-trifluoromethyl-2,3,5,6-tetrahydroimidazoles and 5-oxo-2-phenyl-4-trifluoromethyl-4,5-dihydro-1H-imidazoles. Radioligand binding was used to study the in fluence of the synthesized compounds on the neuronal NMDA receptors.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, O. A. Dranyi & V. V. Grigoriev

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. O. A. Dranyi
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  4. V. V. Grigoriev
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Corresponding author

Correspondence to A. Yu. Aksinenko.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2253–2258, December, 2018.

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Sokolov, V.B., Aksinenko, A.Y., Dranyi, O.A. et al. Methyl esters of 2-aminotetrahydrobenzothiophene-3-carboxylic acids decorated with trifluoromethyl-containing heterocycles. Russ Chem Bull 67, 2253–2258 (2018). https://doi.org/10.1007/s11172-018-2365-3

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  • DOI: https://doi.org/10.1007/s11172-018-2365-3

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