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2H-Benzimidazole N-oxides: synthesis, chemical properties, and biological activity

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Abstract

The review presents and summarizes comprehensive data starting from 2006 on the synthesis of mono- and di-N-oxides of 2H-benzimidazoles and their chemical properties. Especial attention was paid to the chemical transformations of 2H-benzimidazole 1,3-dioxides upon heating to give 3H-2,1,4-benzoxadiazine 4-oxides and 2H-benzimidazole mono-N-oxides. The biological activity of compounds was covered.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation

    E. A. Chugunova, A. S. Gazizov, A. R. Burilov, M. A. Pudovik & O. G. Sinyashin

  2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrentieva, 630090, Novosibirsk, Russian Federation

    V. A. Samsonov

Authors
  1. E. A. Chugunova
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  2. V. A. Samsonov
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  3. A. S. Gazizov
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  4. A. R. Burilov
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  5. M. A. Pudovik
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  6. O. G. Sinyashin
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Correspondence to E. A. Chugunova.

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Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 1955–1970, November, 2018.

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Chugunova, E.A., Samsonov, V.A., Gazizov, A.S. et al. 2H-Benzimidazole N-oxides: synthesis, chemical properties, and biological activity. Russ Chem Bull 67, 1955–1970 (2018). https://doi.org/10.1007/s11172-018-2315-0

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  • DOI: https://doi.org/10.1007/s11172-018-2315-0

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