Russian Chemical Bulletin

, Volume 65, Issue 3, pp 692–696 | Cite as

Iron-containing nanoparticles based on the 2-hydroxypropyl-β-cyclodextrin in aqueous solutions

  • V. V. Spiridonov
  • I. G. Panova
  • A. N. Zakharov
  • I. N. Topchieva
Full Articles


The water-soluble hybrid nanoparticles based on high-substituted 2-hydroxypropyl-β-cyclodextrin were formed in situ during the reduction of iron(+2) salts by hypophosphite ion in alkaline medium. These nanoparticles are high sensitive to temperature and ultrasonication. It was established that the temperature and ultrasonication time of exposure increase leads to the successive dissociation of the nanoparticles.

Key words

2-hydroxypropyl-β-cyclodextrin hybrid nanoparticles thermostability ultrasonication 


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  1. 1.
    G. M. Whitesides, J. P. Mathias, C. Seto, Science, 1991, 254, 1312.CrossRefGoogle Scholar
  2. 2.
    H. Zhang, M.-L. Peng, Y.-L. Cui, C. Chen, J. Chin. Chem., 2008, 26, 1737.CrossRefGoogle Scholar
  3. 3.
    H.-B. Xia, J. Yi, P. S. Foo, B. Liu, Chem. Mater., 2007, 19, 4087.CrossRefGoogle Scholar
  4. 4.
    M. M. Yallapua, S. F. Othmanb, E. T. Curtisb, B. K. Guptaa, M. Jaggia, S. C. Chauhana, Biomaterials, 2011, 32, 1890.CrossRefGoogle Scholar
  5. 5.
    V. V. Spiridonov, A. N. Zakharov, I. G. Panova, M. I. Afanasov, N. S. Perov, I. N. Topchieva, Colloid Polym. Sci., 2015; DOI: 10.1007/s00396-015-3514-y.Google Scholar
  6. 6.
    T. Loftsson, M. E. Brewster, M. Masson, Am._J. Drug Deliv., 2004, 2, 261.CrossRefGoogle Scholar
  7. 7.
    R. L. Carrier, L. A. Miller, L. A. Ahmed, I. Felton, C. J. Wiley, D. A. Godwin, Drug. Dev. Ind. Pharm., 2002, 28, 1117.CrossRefGoogle Scholar
  8. 8.
    Y. Zheng, A. H. L. Chow, Drug Dev. Ind. Pharm., 2009, 35, 727.CrossRefGoogle Scholar
  9. 9.
    F. J. Otero-Espinar, J. J. Torres-Labandeira, C. AlvarezLorenzo, J. Blanco-Méndez, J. Drug Del. Sci. Tech., 2010, 20, 289.CrossRefGoogle Scholar
  10. 10.
    I. Hayashi, K. Ono, H. Suzuki, M. Sawada, M. Moriya, W. Sakamoto, T. Yogo, Appl. Mater. Interfaces, 2010, 2, 1903.CrossRefGoogle Scholar
  11. 11.
    Pat. RF No. 2453499; Scholar
  12. 12.
    M. Mäkelä, T. Korpela, S. J. Laakso, J. Biochem. Biophys. Methods, 1987, 14.Google Scholar
  13. 13.
    K. J. Sasaki, C. S. D. Chtistian, E. E. Tucker, Fluid Phase Equilib., 1989, 49, 281.CrossRefGoogle Scholar
  14. 14.
    I. N. Topchieva, V. V. Spiridonov, F. A. Kalashnikov, B. I. Kurganov, Colloid J., 2005, 68, 105 [Colloid. J. (Engl. Transl.), 2005, 68, No. 1].Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • V. V. Spiridonov
    • 1
  • I. G. Panova
    • 1
  • A. N. Zakharov
    • 1
  • I. N. Topchieva
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

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