Synthesis and antimycobacterial activity of some benzyl- and methylisocyanurate derivatives
Alkylation of methyl thioglycolate with ω-(haloalkyl) derivatives of 1-benzyland 1-methylisocyanurates yielded 1,3-bis[ω-(methoxycarbonylmethylthio)alkyl)]-5-benzyl(methyl)isocyanurates. Treatment of these compounds with ammonia or hydrazine hydrate and subsequent oxidation with hydrogen peroxide gives 1-benzylor 1-methylisocyanurates bearing two pharmacophoric substituents (i.e., carbamoyl, or carbazoylmethylsulfinyl, or sulfonyl groups) in the N-alkyl chains. The synthesized compounds exhibited antimycobacterial activity.
Key wordsisocyanurate sulfides oxidation sulfones sulfoxides amides hydrazides antimycobacterial activity
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